MGP Database

MGP000856

Ontology/Pathway Information

Entrez Gene ID	1789
Gene Name	DNA (cytosine-5-)-methyltransferase 3 beta
Gene Symbol	DNMT3B
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0000775	IEA:Ensembl	C	chromosome, centromeric region
GO:0005737	IEA:Ensembl	C	cytoplasm
GO:0043231	IDA:HPA	C	intracellular membrane-bounded organelle
GO:0005720	IEA:Ensembl	C	nuclear heterochromatin
GO:0005634	IDA:UniProtKB	C	nucleus
GO:0003886	NAS:UniProtKB	F	DNA (cytosine-5-)-methyltransferase activity
GO:0051718	IEA:Ensembl	F	DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates
GO:0009008	NAS:UniProtKB	F	DNA-methyltransferase activity
GO:0046872	IEA:UniProtKB-KW	F	metal ion binding
GO:0003714	IDA:UniProtKB	F	transcription corepressor activity
GO:0045322	IEA:Ensembl	F	unmethylated CpG binding
GO:0090116	IDA:GOC	P	C-5 methylation of cytosine
GO:0071230	IEA:Ensembl	P	cellular response to amino acid stimulus
GO:0006306	NAS:UniProtKB	P	DNA methylation
GO:0043045	IEA:Ensembl	P	DNA methylation involved in embryo development
GO:0010424	IEA:Ensembl	P	DNA methylation on cytosine within a CG sequence
GO:0006346	IEA:Ensembl	P	methylation-dependent chromatin silencing
GO:0051573	IMP:UniProtKB	P	negative regulation of histone H3-K9 methylation
GO:0000122	IDA:UniProtKB	P	negative regulation of transcription from RNA polymerase II promoter
GO:0010628	IMP:UniProtKB	P	positive regulation of gene expression
GO:0051571	IMP:UniProtKB	P	positive regulation of histone H3-K4 methylation
GO:0045666	IEA:Ensembl	P	positive regulation of neuron differentiation
GO:0031503	IEA:Ensembl	P	protein complex localization
GO:0006349	IEA:Ensembl	P	regulation of gene expression by genetic imprinting
GO:0042493	IEA:Ensembl	P	response to drug
GO:0010212	IEA:Ensembl	P	response to ionizing radiation
GO:0046498	IEA:Ensembl	P	S-adenosylhomocysteine metabolic process
GO:0046499	IEA:Ensembl	P	S-adenosylmethioninamine metabolic process

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_268237	DNA methylation
REACT_264098	Epigenetic regulation of gene expression
REACT_71	Gene Expression
REACT_264000	Negative epigenetic regulation of rRNA expression
REACT_263965	NoRC negatively regulates rRNA expression
REACT_264352	PRC2 methylates histones and DNA