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MGP000859

UniProt Annotations

Entry Information
Gene Namedocking protein 1, 62kDa (downstream of tyrosine kinase 1)
Protein EntryDOK1_HUMAN
UniProt IDQ99704
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing, Alternative initiation; Named isoforms=3; Name=1; Synonyms=p62Dok1; IsoId=Q99704-1; Sequence=Displayed; Name=2; Synonyms=p22Dokdel; IsoId=Q99704-2; Sequence=VSP_003852, VSP_003853; Name=3; Synonyms=p44Dok; IsoId=Q99704-3; Sequence=VSP_038224; Note=Produced by alternative initiation at Met-140 of isoform 1. Contains a N-acetylmethionine at position 1.;
DomainThe PTB domain mediates receptor interaction.
FunctionDOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3. {ECO:0000269|PubMed:18156175}.
InteractionQ9JIY2:Cbll1 (xeno); NbExp=2; IntAct=EBI-1384360, EBI-7644904; P04626:ERBB2; NbExp=2; IntAct=EBI-1384360, EBI-641062; Q9Q2G4:ORF (xeno); NbExp=2; IntAct=EBI-1384360, EBI-6248094; Q9H3Y6:SRMS; NbExp=7; IntAct=EBI-1384360, EBI-8541270;
PtmConstitutively tyrosine-phosphorylated. Phosphorylated by TEC (By similarity). Phosphorylated by LYN (By similarity). Phosphorylated on tyrosine residues by the insulin receptor kinase. Results in the negative regulation of the insulin signaling pathway. Phosphorylated on tyrosine residues by SRMS. {ECO:0000250, ECO:0000269|PubMed:11551902, ECO:0000269|PubMed:15592455, ECO:0000269|PubMed:18088087, ECO:0000269|PubMed:18669648, ECO:0000269|PubMed:19690332, ECO:0000269|PubMed:23822091, ECO:0000269|PubMed:9008160}.
PtmIsoform 3 contains a N-acetylmethionine at position 1.
SimilarityBelongs to the DOK family. Type A subfamily. {ECO:0000305}.
SimilarityContains 1 IRS-type PTB domain. {ECO:0000255|PROSITE- ProRule:PRU00389}.
SimilarityContains 1 PH domain. {ECO:0000305}.
Subcellular LocationIsoform 1: Cytoplasm. Nucleus.
Subcellular LocationIsoform 3: Cytoplasm, perinuclear region.
SubunitInteracts with ABL1 (By similarity). Interacts with RasGAP and INPP5D/SHIP1. Interacts directly with phosphorylated ITGB3. Interacts with SRMS (via the SH2 and SH3 domains). {ECO:0000250, ECO:0000269|PubMed:18156175, ECO:0000269|PubMed:23822091}.
Tissue SpecificityExpressed in pancreas, heart, leukocyte and spleen. Expressed in both resting and activated peripheral blood T-cells. Expressed in breast cancer. {ECO:0000269|PubMed:12595900}.
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