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MGP000862

Record overview

MGPD IDMGP000862
Gene ID1801
SpeciesHomo sapiens (Human)
Gene Namediphthamide biosynthesis 1
Gene Symbol DPH1
SynonymsDPH2L; OVCA1; DPH2L1;
Alternate namesdiphthamide biosynthesis protein 1; DPH-like 1; DPH2-like 1; DPH1 homolog; ovarian tumor suppressor candidate 1; ovarian cancer-associated gene 1 protein; candidate tumor suppressor in ovarian cancer 1; diphthamide biosynthesis protein 2 homolog-like 1; diptheria toxin resistance protein required for diphthamide biosynthesis-like 1; diptheria toxin resistance protein required for diphthamide biosynthesis (Saccharomyces)-like 1;
Chromosome17
Map Location17p13.3
SummaryDiphthamide is a unique posttranslationally modified histidine found only in translation elongation factor-2 (EEF2; MIM 130610). This modification is conserved from archaebacteria to humans and serves as the target for ADP-ribosylation and inactivation of EEF2 by diphtheria toxin (DT) and Pseudomonas exotoxin A. DPH1 is 1 of several enzymes involved in synthesis of diphthamide in EEF2 (Liu et al., 2004 [PubMed 15485916]).[supplied by OMIM, Mar 2008]
OrthologsView orthologs and multiple alignments for DPH1

Proteins

diphthamide biosynthesis protein 1
Refseq ID:NP_001374
Protein GI:116686106
UniProt ID:Q9BZG8
mRNA ID:NM_001383
Length:443
RefSeq Status:
MRRQVMAALVVSGAAEQGGRDGPGRGRAPRGRVANQIPPEILKNPQLQAAIRVLPSNYNFEIPKTIWRIQQAQAKKVALQMPEGLLLFACTIVDILERFT
EAEVMVMGDVTYGACCVDDFTARALGADFLVHYGHSCLIPMDTSAQDFRVLYVFVDIRIDTTHLLDSLRLTFPPATALALVSTIQFVSTLQAAAQELKAE
YRVSVPQCKPLSPGEILGCTSPRLSKEVEAVVYLGDGRFHLESVMIANPNVPAYRYDPYSKVLSREHYDHQRMQAARQEAIATARSAKSWGLILGTLGRQ
GSPKILEHLESRLRALGLSFVRLLLSEIFPSKLSLLPEVDVWVQVACPRLSIDWGTAFPKPLLTPYEAAVALRDISWQQPYPMDFYAGSSLGPWTVNHGQ
DRRPHAPGRPARGKVQEGSARPPSAVACEDCSCRDEKVAPLAP
 
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