MGP Database

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MGP000863

Record overview

MGPD IDMGP000863
Gene ID1802
SpeciesHomo sapiens (Human)
Gene NameDPH2 homolog (S. cerevisiae)
Gene Symbol DPH2
SynonymsDPH2L2;
Alternate namesdiphthamide biosynthesis protein 2; DPH2-like 2; diphthamide biosynthesis-like protein 2; diphthamide biosynthesis protein 2 homolog-like 2; diptheria toxin resistance protein required for diphthamide biosynthesis-like 2;
Chromosome1
Map Location1p34
SummaryThis gene is one of two human genes similar to the yeast gene dph2. The yeast gene was identified by its ability to complement a diphthamide mutant strain, and thus probably functions in diphthamide biosynthesis. Diphthamide is a post-translationally modified histidine residue present in elongation factor 2 (EF2) that is the target of diphtheria toxin ADP-ribosylation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for DPH2

Proteins

diphthamide biosynthesis protein 2 isoform a
Refseq ID:NP_001375
Protein GI:21536476
UniProt ID:Q9BQC3
mRNA ID:NM_001384
Length:489
RefSeq Status:
MESMFSSPAEAALQRETGVPGLLTPLPDLDGVYELERVAGFVRDLGCERVALQFPDQLLGDAVAVAARLEETTGSKMFILGDTAYGSCCVDVLGAEQAGA
QALIHFGPACLSPPARPLPVAFVLRQRSVALELCVKAFEAQNPDPKAPVVLLSEPACAHALEALATLLRPRYLDLLVSSPAFPQPVGSLSPEPMPLERFG
RRFPLAPGRRLEEYGAFYVGGSKASPDPDLDPDLSRLLLGWAPGQPFSSCCPDTGKTQDEGARAGRLRARRRYLVERARDARVVGLLAGTLGVAQHREAL
AHLRNLTQAAGKRSYVLALGRPTPAKLANFPEVDVFVLLACPLGALAPQLSGSFFQPILAPCELEAACNPAWPPPGLAPHLTHYADLLPGSPFHVALPPP
ESELWETPDVSLITGDLRPPPAWKSSNDHGSLALTPRPQLELAESSPAASFLSSRSWQGLEPRLGQTPVTEAVSGRRGIAIAYEDEGSG
 
diphthamide biosynthesis protein 2 isoform b
Refseq ID:NP_001034678
Protein GI:88853059
UniProt ID:Q9BQC3
mRNA ID:NM_001039589
Length:261
RefSeq Status:
MESMFSSPAEAALQRETGVPGLLTPLPDLDGVYELERVAGFVRDLGCERVALQFPDQLLGDAVAVAARLEETTGSKMFILGDTAYGSCCVDVLGAEQAGA
QALIHFGPACLSPPARPLPVAFVLRQRSVALELCVKAFEAQNPDPKAPVVLLSEPACAHALGSPFHVALPPPESELWETPDVSLITGDLRPPPAWKSSND
HGSLALTPRPQLELAESSPAASFLSSRSWQGLEPRLGQTPVTEAVSGRRGIAIAYEDEGSG
 
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