MGP Database

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MGP000865

Ontology/Pathway Information

Entrez Gene ID1806
Gene Namedihydropyrimidine dehydrogenase
Gene Symbol DPYD
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005737 IDA:UniProtKBCcytoplasm
GO:0005829 IDA:UniProtKBCcytosol
GO:0051539 IEA:UniProtKB-KWF4 iron, 4 sulfur cluster binding
GO:0004152 IEA:InterProFdihydroorotate dehydrogenase activity
GO:0017113 IDA:UniProtKBFdihydropyrimidine dehydrogenase (NADP+) activity
GO:0050660 ISS:UniProtKBFflavin adenine dinucleotide binding
GO:0046872 IEA:UniProtKB-KWFmetal ion binding
GO:0050661 ISS:UniProtKBFNADP binding
GO:0042803 IDA:UniProtKBFprotein homodimerization activity
GO:0019483 IEA:UniProtKB-UniPathwayPbeta-alanine biosynthetic process
GO:0055086 TAS:ReactomePnucleobase-containing small molecule metabolic process
GO:0006145 IMP:UniProtKBPpurine nucleobase catabolic process
GO:0006208 IMP:UniProtKBPpyrimidine nucleobase catabolic process
GO:0006206 TAS:ReactomePpyrimidine nucleobase metabolic process
GO:0046135 TAS:ReactomePpyrimidine nucleoside catabolic process
GO:0044281 TAS:ReactomePsmall molecule metabolic process
GO:0006214 IDA:UniProtKBPthymidine catabolic process
GO:0006210 IDA:UniProtKBPthymine catabolic process
GO:0006222 IEA:InterProPUMP biosynthetic process
GO:0006212 IDA:UniProtKBPuracil catabolic process
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_111217Metabolism
REACT_1698Metabolism of nucleotides
REACT_1023Pyrimidine catabolism
REACT_957Pyrimidine metabolism
SMP Pathway Links
SMP IDDescription
SMP00007Beta-Alanine Metabolism
SMP00172Beta Ureidopropionase Deficiency
SMP00493Carnosinuria, carnosinemia
SMP00178Dihydropyrimidinase Deficiency
SMP00351GABA-Transaminase Deficiency
SMP00202MNGIE (Mitochondrial Neurogastrointestinal Encephalopathy)
SMP00046Pyrimidine Metabolism
SMP00219UMP Synthase Deiciency (Orotic Aciduria)
SMP00492Ureidopropionase deficiency
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