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MGP000866

Record overview

MGPD IDMGP000866
Gene ID1807
SpeciesHomo sapiens (Human)
Gene Namedihydropyrimidinase
Gene Symbol DPYS
SynonymsDHP; DHPase;
Alternate namesdihydropyrimidinase; hydantoinase; dihydropyrimidine amidohydrolase;
Chromosome8
Map Location8q22
EC Number3.5.2.2
SummaryDihydropyrimidinase catalyzes the conversion of 5,6-dihydrouracil to 3-ureidopropionate in pyrimidine metabolism. Dihydropyrimidinase is expressed at a high level in liver and kidney as a major 2.5-kb transcript and a minor 3.8-kb transcript. Defects in the DPYS gene are linked to dihydropyrimidinuria. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for DPYS

Proteins

dihydropyrimidinase
Refseq ID:NP_001376
Protein GI:4503375
UniProt ID:Q14117
mRNA ID:NM_001385
Length:519
RefSeq Status:
MAAPSRLLIRGGRVVNDDFSEVADVLVEDGVVRALGHDLLPPGGAPAGLRVLDAAGKLVLPGGIDTHTHMQFPFMGSRSIDDFHQGTKAALSGGTTMIID
FAIPQKGGSLIEAFETWRSWADPKVCCDYSLHVAVTWWSDQVKEEMKILVQDKGVNSFKMFMAYKDLYMVTDLELYEAFSRCKEIGAIAQVHAENGDLIA
EGAKKMLALGITGPEGHELCRPEAVEAEATLRAITIASAVNCPLYIVHVMSKSAAKVIADARRDGKVVYGEPIAASLGTDGTHYWNKEWHHAAHHVMGPP
LRPDPSTPDFLMNLLANDDLTTTGTDNCTFNTCQKALGKDDFTKIPNGVNGVEDRMSVIWEKGVHSGKMDENRFVAVTSTNAAKIFNLYPRKGRIAVGSD
ADIVIWDPKGTRTISAKTHHQAVNFNIFEGMVCHGVPLVTISRGKVVYEAGVFSVTAGDGKFIPRKPFAEYIYKRIKQRDRTCTPTPVERAPYKGEVATL
KSRVTKEDATAGTRKQAHP
 
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