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MGP000867

UniProt Annotations

Entry Information
Gene Namedihydropyrimidinase-like 2
Protein EntryDPYL2_HUMAN
UniProt IDQ16555
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q16555-1; Sequence=Displayed; Name=2; IsoId=Q16555-2; Sequence=VSP_044941; Note=No experimental confirmation available.;
CautionLacks most of the conserved residues that are essential for binding the metal cofactor and hence for dihydropyrimidinase activity. Its enzyme activity is therefore unsure. {ECO:0000305}.
FunctionPlays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis. {ECO:0000269|PubMed:11477421, ECO:0000269|PubMed:15466863, ECO:0000269|PubMed:20801876}.
Ptm3F4, a monoclonal antibody which strongly stains neurofibrillary tangles in Alzheimer disease brains, specifically labels DPYSL2 when phosphorylated on Ser-518, Ser-522 and Thr-509. {ECO:0000269|PubMed:10757975, ECO:0000269|PubMed:15466863, ECO:0000269|PubMed:16964243, ECO:0000269|PubMed:18669648, ECO:0000269|PubMed:21406692}.
PtmPhosphorylation at Thr-514 by GSK3B abolishes tubulin-binding leading to destabilization of microtubule assembly in axons and neurodegeneration (By similarity). Phosphorylation by DYRK2 at Ser-522 is required for subsequent phosphorylation by GSK3B. {ECO:0000250, ECO:0000269|PubMed:10757975, ECO:0000269|PubMed:15466863, ECO:0000269|PubMed:16964243, ECO:0000269|PubMed:21406692}.
SimilarityBelongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily. {ECO:0000305}.
Subcellular LocationCytoplasm, cytosol {ECO:0000269|PubMed:20801876}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:20801876}. Membrane {ECO:0000269|PubMed:20801876}. Note=Tightly but non-covalently associated with membranes.
SubunitHomotetramer, and heterotetramer with CRMP1, DPYSL3, DPYSL4 or DPYSL5. Interacts through its C-terminus with the C- terminus of CYFIP1/SRA1. Interacts with HTR4. Interacts with CLN6. Interacts with MICALL1. {ECO:0000269|PubMed:14685275, ECO:0000269|PubMed:16260607, ECO:0000269|PubMed:17250651, ECO:0000269|PubMed:19235893, ECO:0000269|PubMed:20801876}.
Tissue SpecificityUbiquitous.
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