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MGP000868

UniProt Annotations

Entry Information
Gene Namedihydropyrimidinase-like 3
Protein EntryDPYL3_HUMAN
UniProt IDQ14195
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q14195-1; Sequence=Displayed; Name=LCRMP-4; IsoId=Q14195-2; Sequence=VSP_042546; Note=Contains a phosphoserine at position 102.;
CautionLacks most of the conserved residues that are essential for binding the metal cofactor and hence for dihydropyrimidinase activity. Its enzyme activity is therefore unsure. {ECO:0000305}.
FunctionNecessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity). {ECO:0000250}.
PtmPhosphorylation on Ser-522 by DYRK2 promotes subsequent phosphorylation on Thr-509, Thr-514 and Ser-518 by GSK3. {ECO:0000269|PubMed:16611631, ECO:0000269|PubMed:21406692}.
SimilarityBelongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily. {ECO:0000305}.
Subcellular LocationCytoplasm {ECO:0000250}. Cell projection, growth cone {ECO:0000250}. Note=Colocalizes with synaptic vesicle protein 2 in the central region of the growth cone. {ECO:0000250}.
SubunitHomotetramer, and heterotetramer with CRMP1, DPYSL2, DPYSL4 or DPYSL5. Interacts with synaptic vesicle protein 2 and SH3A domain of intersectin. {ECO:0000250}.
Tissue SpecificityMainly expressed in heart and skeletal muscle. Also strongly expressed in fetal brain and spinal cord.
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