MGP Database

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MGP000879

UniProt Annotations

Entry Information
Gene Namedesmoglein 3
Protein EntryDSG3_HUMAN
UniProt IDP32926
SpeciesHuman
Comments
Comment typeDescription
DomainThree calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain. {ECO:0000250}.
FunctionComponent of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
MiscellaneousPemphigus vulgaris (PV) is a potentially lethal skin disease in which epidermal blisters occur as the result of the loss of cell-cell adhesion caused by the action of autoantibodies against desmoglein 3.
SimilarityContains 4 cadherin domains. {ECO:0000255|PROSITE- ProRule:PRU00043}.
Subcellular LocationCell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cell junction, desmosome {ECO:0000250}.
Tissue SpecificityEpidermis, tongue, tonsil, esophagus and carcinomas.
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