MGP Database

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MGP000884

Ontology/Pathway Information

Entrez Gene ID1839
Gene Nameheparin-binding EGF-like growth factor
Gene Symbol HBEGF
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0009986 NAS:UniProtKBCcell surface
GO:0005576 TAS:ReactomeCextracellular region
GO:0005615 TAS:UniProtKBCextracellular space
GO:0005887 TAS:UniProtKBCintegral component of plasma membrane
GO:0005154 TAS:ProtIncFepidermal growth factor receptor binding
GO:0008083 IDA:UniProtKBFgrowth factor activity
GO:0008201 IMP:UniProtKBFheparin binding
GO:0007173 IMP:BHF-UCLPepidermal growth factor receptor signaling pathway
GO:0038095 TAS:ReactomePFc-epsilon receptor signaling pathway
GO:0008543 TAS:ReactomePfibroblast growth factor receptor signaling pathway
GO:0045087 TAS:ReactomePinnate immune response
GO:0007517 TAS:ProtIncPmuscle organ development
GO:0051545 IEA:EnsemblPnegative regulation of elastin biosynthetic process
GO:0048011 TAS:ReactomePneurotrophin TRK receptor signaling pathway
GO:0048015 TAS:ReactomePphosphatidylinositol-mediated signaling
GO:0030307 IEA:EnsemblPpositive regulation of cell growth
GO:0030335 IMP:BHF-UCLPpositive regulation of cell migration
GO:0051549 IEA:EnsemblPpositive regulation of keratinocyte migration
GO:0051897 IMP:BHF-UCLPpositive regulation of protein kinase B signaling
GO:0048661 IEA:EnsemblPpositive regulation of smooth muscle cell proliferation
GO:0090303 IMP:BHF-UCLPpositive regulation of wound healing
GO:0008016 IEA:EnsemblPregulation of heart contraction
GO:0007165 TAS:ProtIncPsignal transduction
GO:0035313 IEA:EnsemblPwound healing, spreading of epidermal cells
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_75774Adaptive Immune System
REACT_147727Constitutive PI3K/AKT Signaling in Cancer
REACT_147694DAP12 interactions
REACT_147814DAP12 signaling
REACT_116125Disease
REACT_118638Downstream signaling events of B Cell Receptor (BCR)
REACT_21272Downstream signaling of activated FGFR
REACT_17025Downstream signal transduction
REACT_121096EGFR Transactivation by Gastrin
REACT_163936Fc epsilon receptor (FCERI) signaling
REACT_12578GAB1 signalosome
REACT_120966Gastrin-CREB signalling pathway via PKC and MAPK
REACT_115854GRB2 events in ERBB2 signaling
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_116022Nuclear signaling by ERBB4
REACT_12464PI3K/AKT activation
REACT_147723PI3K/AKT Signaling in Cancer
REACT_21270PI-3K cascade
REACT_116008PI3K events in ERBB2 signaling
REACT_115961PI3K events in ERBB4 signaling
REACT_75829PIP3 activates AKT signaling
REACT_163769Role of LAT2/NTAL/LAB on calcium mobilization
REACT_115993SHC1 events in ERBB2 signaling
REACT_116005SHC1 events in ERBB4 signaling
REACT_9417Signaling by EGFR
REACT_115871Signaling by EGFR in Cancer
REACT_268269Signaling by EGFRvIII in Cancer
REACT_115755Signaling by ERBB2
REACT_115596Signaling by ERBB4
REACT_9470Signaling by FGFR
REACT_120736Signaling by FGFR in disease
REACT_14797Signaling by GPCR
REACT_268006Signaling by Ligand-Responsive EGFR Variants in Cancer
REACT_268546Signaling by Overexpressed Wild-Type EGFR in Cancer
REACT_16888Signaling by PDGF
REACT_111040Signaling by SCF-KIT
REACT_118773Signaling by the B Cell Receptor (BCR)
REACT_11061Signalling by NGF
REACT_111102Signal Transduction
REACT_264041Uptake and actions of bacterial toxins
REACT_268571Uptake and function of diphtheria toxin
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