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MGP000888

UniProt Annotations

Entry Information
Gene Namedual specificity phosphatase 4
Protein EntryDUS4_HUMAN
UniProt IDQ13115
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; Synonyms=MKP-2-L; IsoId=Q13115-1; Sequence=Displayed; Name=2; Synonyms=MKP-2-S; IsoId=Q13115-2; Sequence=VSP_044667, VSP_044668; Note=Does not bind to JNK or ERK, and is more susceptible to proteosomal degradation.;
Catalytic Activity[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.
Catalytic ActivityProtein tyrosine phosphate + H(2)O = protein tyrosine + phosphate. {ECO:0000255|PROSITE-ProRule:PRU10044}.
FunctionRegulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2.
PtmPhosphorylation in the C-terminus by ERK1/2 inhibits proteasomal degradation and stabilizes the protein. {ECO:0000269|PubMed:21084841}.
SimilarityBelongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. {ECO:0000305}.
SimilarityContains 1 rhodanese domain. {ECO:0000255|PROSITE- ProRule:PRU00173}.
SimilarityContains 1 tyrosine-protein phosphatase domain. {ECO:0000305}.
Subcellular LocationNucleus.
SubunitHollow spherical complex composed of 24 subunits with pseudooctahedral symmetry, has a tetramer as the basic unit. {ECO:0000269|PubMed:19415758}.
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