MGP Database

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MGP000889

Ontology/Pathway Information

Entrez Gene ID1848
Gene Namedual specificity phosphatase 6
Gene Symbol DUSP6
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005737 IDA:UniProtKBCcytoplasm
GO:0005829 IEA:EnsemblCcytosol
GO:0005654 TAS:ReactomeCnucleoplasm
GO:0017017 IDA:UniProtKBFMAP kinase tyrosine/serine/threonine phosphatase activity
GO:0004725 IEA:UniProtKB-ECFprotein tyrosine phosphatase activity
GO:0030154 IEA:EnsemblPcell differentiation
GO:0009953 IBA:RefGenomePdorsal/ventral pattern formation
GO:0000188 IDA:UniProtKBPinactivation of MAPK activity
GO:0045087 TAS:ReactomePinnate immune response
GO:0002755 TAS:ReactomePMyD88-dependent toll-like receptor signaling pathway
GO:0002756 TAS:ReactomePMyD88-independent toll-like receptor signaling pathway
GO:0070373 IMP:UniProtKBPnegative regulation of ERK1 and ERK2 cascade
GO:0048011 TAS:ReactomePneurotrophin TRK receptor signaling pathway
GO:0035335 IDA:UniProtKBPpeptidyl-tyrosine dephosphorylation
GO:0043065 IDA:UniProtKBPpositive regulation of apoptotic process
GO:0042663 IBA:RefGenomePregulation of endodermal cell fate specification
GO:0040036 IBA:RefGenomePregulation of fibroblast growth factor receptor signaling pathway
GO:0060420 IBA:RefGenomePregulation of heart growth
GO:0042493 IEA:EnsemblPresponse to drug
GO:0051409 IEP:UniProtKBPresponse to nitrosative stress
GO:0014070 IEA:EnsemblPresponse to organic cyclic compound
GO:0051403 TAS:ReactomePstress-activated MAPK cascade
GO:0034166 TAS:ReactomePtoll-like receptor 10 signaling pathway
GO:0034134 TAS:ReactomePtoll-like receptor 2 signaling pathway
GO:0034138 TAS:ReactomePtoll-like receptor 3 signaling pathway
GO:0034142 TAS:ReactomePtoll-like receptor 4 signaling pathway
GO:0034146 TAS:ReactomePtoll-like receptor 5 signaling pathway
GO:0034162 TAS:ReactomePtoll-like receptor 9 signaling pathway
GO:0002224 TAS:ReactomePtoll-like receptor signaling pathway
GO:0038123 TAS:ReactomePtoll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 TAS:ReactomePtoll-like receptor TLR6:TLR2 signaling pathway
GO:0035666 TAS:ReactomePTRIF-dependent toll-like receptor signaling pathway
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_6890Activated TLR4 signalling
REACT_12599ERK/MAPK targets
REACT_12436ERKs are inactivated
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_21308MAP kinase activation in TLR cascade
REACT_21328MAPK targets/ Nuclear events mediated by MAP kinases
REACT_27215MyD88 cascade initiated on plasma membrane
REACT_25222MyD88 dependent cascade initiated on endosome
REACT_6809MyD88-independent cascade
REACT_6788MyD88:Mal cascade initiated on plasma membrane
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_12433Nuclear Events (kinase and transcription factor activation)
REACT_11061Signalling by NGF
REACT_111102Signal Transduction
REACT_9027Toll Like Receptor 10 (TLR10) Cascade
REACT_7980Toll Like Receptor 2 (TLR2) Cascade
REACT_6783Toll Like Receptor 3 (TLR3) Cascade
REACT_6894Toll Like Receptor 4 (TLR4) Cascade
REACT_9061Toll Like Receptor 5 (TLR5) Cascade
REACT_9020Toll Like Receptor 7/8 (TLR7/8) Cascade
REACT_9047Toll Like Receptor 9 (TLR9) Cascade
REACT_6966Toll-Like Receptors Cascades
REACT_8005Toll Like Receptor TLR1:TLR2 Cascade
REACT_8006Toll Like Receptor TLR6:TLR2 Cascade
REACT_25024TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
REACT_25281TRIF-mediated TLR3/TLR4 signaling
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