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MGP000890

Record overview

MGPD IDMGP000890
Gene ID1849
SpeciesHomo sapiens (Human)
Gene Namedual specificity phosphatase 7
Gene Symbol DUSP7
SynonymsMKPX; PYST2;
Alternate namesdual specificity protein phosphatase 7; dual-specificity phosphatase-7; dual specificity protein phosphatase PYST2;
Chromosome3
Map Location3p21
EC Number3.1.3.16
SummaryDual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. DUSP7 belongs to a class of DUSPs, designated MKPs, that dephosphorylate MAPK (mitogen-activated protein kinase) proteins ERK (see MIM 601795), JNK (see MIM 601158), and p38 (see MIM 600289) with specificity distinct from that of individual MKP proteins. MKPs contain a highly conserved C-terminal catalytic domain and an N-terminal Cdc25 (see MIM 116947)-like (CH2) domain. MAPK activation cascades mediate various physiologic processes, including cellular proliferation, apoptosis, differentiation, and stress responses (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009]
OrthologsView orthologs and multiple alignments for DUSP7

Proteins

dual specificity protein phosphatase 7
Refseq ID:NP_001938
Protein GI:238231453
UniProt ID:Q16829
mRNA ID:NM_001947
Length:419
RefSeq Status:
MKNQLRGPPARAHMSTSGAAAAGGTRAGSEPGAGSGSGAGTGAGAATGAGAMPCKSAEWLQEELEARGGASLLLLDCRPHELFESSHIETAINLAIPGLM
LRRLRKGNLPIRSIIPNHADKERFATRCKAATVLLYDEATAEWQPEPGAPASVLGLLLQKLRDDGCQAYYLQGGFNKFQTEYSEHCETNVDSSSSPSSSP
PTSVLGLGGLRISSDCSDGESDRELPSSATESDGSPVPSSQPAFPVQILPYLYLGCAKDSTNLDVLGKYGIKYILNVTPNLPNAFEHGGEFTYKQIPISD
HWSQNLSQFFPEAISFIDEARSKKCGVLVHCLAGISRSVTVTVAYLMQKMNLSLNDAYDFVKRKKSNISPNFNFMGQLLDFERTLGLSSPCDNHASSEQL
YFSTPTNHNLFPLNTLEST
 
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