MGP Database

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MGP000905

UniProt Annotations

Entry Information
Gene Namesphingosine-1-phosphate receptor 3
Protein EntryS1PR3_HUMAN
UniProt IDQ99500
SpeciesHuman
Comments
Comment typeDescription
FunctionReceptor for the lysosphingolipid sphingosine 1- phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis. {ECO:0000269|PubMed:10617617}.
SimilarityBelongs to the G-protein coupled receptor 1 family. {ECO:0000255|PROSITE-ProRule:PRU00521}.
Subcellular LocationCell membrane; Multi-pass membrane protein.
Tissue SpecificityExpressed in all tissues, but most abundantly in heart, placenta, kidney, and liver.
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