MGP Database

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MGP000908

Ontology/Pathway Information

Entrez Gene ID1908
Gene Nameendothelin 3
Gene Symbol EDN3
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005576 TAS:ReactomeCextracellular region
GO:0005615 IDA:BHF-UCLCextracellular space
GO:0005179 IDA:BHF-UCLFhormone activity
GO:0005102 TAS:ProtIncFreceptor binding
GO:0008015 TAS:ProtIncPblood circulation
GO:0007267 TAS:ProtIncPcell-cell signaling
GO:0007166 IDA:BHF-UCLPcell surface receptor signaling pathway
GO:0048016 IDA:BHF-UCLPinositol phosphate-mediated signaling
GO:0030318 IEA:EnsemblPmelanocyte differentiation
GO:0007275 TAS:ProtIncPmulticellular organismal development
GO:0001755 IEA:EnsemblPneural crest cell migration
GO:0030182 IEA:EnsemblPneuron differentiation
GO:0030593 IDA:BHF-UCLPneutrophil chemotaxis
GO:0030072 IDA:BHF-UCLPpeptide hormone secretion
GO:0008284 IEA:EnsemblPpositive regulation of cell proliferation
GO:0010460 IDA:BHF-UCLPpositive regulation of heart rate
GO:0046887 IDA:BHF-UCLPpositive regulation of hormone secretion
GO:0002690 IDA:BHF-UCLPpositive regulation of leukocyte chemotaxis
GO:0043406 IDA:BHF-UCLPpositive regulation of MAP kinase activity
GO:0045840 IDA:BHF-UCLPpositive regulation of mitosis
GO:0048070 IEA:EnsemblPregulation of developmental pigmentation
GO:0003100 IDA:BHF-UCLPregulation of systemic arterial blood pressure by endothelin
GO:0019229 IEA:InterProPregulation of vasoconstriction
GO:0007165 TAS:ProtIncPsignal transduction
GO:0042310 IDA:BHF-UCLPvasoconstriction
GO:0014826 IDA:BHF-UCLPvein smooth muscle contraction
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_14828Class A/1 (Rhodopsin-like receptors)
REACT_267874Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
REACT_116125Disease
REACT_18283G alpha (q) signalling events
REACT_120966Gastrin-CREB signalling pathway via PKC and MAPK
REACT_19184GPCR downstream signaling
REACT_21340GPCR ligand binding
REACT_267615Metabolic disorders of biological oxidation enzymes
REACT_14819Peptide ligand-binding receptors
REACT_14797Signaling by GPCR
REACT_111102Signal Transduction
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