MGP Database

MGP000909

Ontology/Pathway Information

Entrez Gene ID	1909
Gene Name	endothelin receptor type A
Gene Symbol	EDNRA
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005887	TAS:ProtInc	C	integral component of plasma membrane
GO:0045121	IEA:Ensembl	C	membrane raft
GO:0031965	IEA:Ensembl	C	nuclear membrane
GO:0005886	TAS:Reactome	C	plasma membrane
GO:0030315	IEA:Ensembl	C	T-tubule
GO:0004962	NAS:UniProtKB	F	endothelin receptor activity
GO:0004435	TAS:ProtInc	F	phosphatidylinositol phospholipase C activity
GO:0007190	TAS:ProtInc	P	activation of adenylate cyclase activity
GO:0007202	TAS:ProtInc	P	activation of phospholipase C activity
GO:0007568	IEA:Ensembl	P	aging
GO:0014824	IMP:BHF-UCL	P	artery smooth muscle contraction
GO:0008283	NAS:UniProtKB	P	cell proliferation
GO:0071260	IEA:Ensembl	P	cellular response to mechanical stimulus
GO:0086100	NAS:GOC	P	endothelin receptor signaling pathway
GO:0048484	IEA:InterPro	P	enteric nervous system development
GO:0048144	IEA:Ensembl	P	fibroblast proliferation
GO:0003094	IEA:Ensembl	P	glomerular filtration
GO:0015758	ISS:UniProtKB	P	glucose transport
GO:0007186	NAS:UniProtKB	P	G-protein coupled receptor signaling pathway
GO:0060322	IEA:Ensembl	P	head development
GO:0007507	IEA:Ensembl	P	heart development
GO:0001821	IEA:Ensembl	P	histamine secretion
GO:0001701	IEA:Ensembl	P	in utero embryonic development
GO:0060137	IEA:Ensembl	P	maternal process involved in parturition
GO:0008152	TAS:GOC	P	metabolic process
GO:0043066	IEA:Ensembl	P	negative regulation of apoptotic process
GO:0030818	IEA:Ensembl	P	negative regulation of cAMP biosynthetic process
GO:0014032	IEA:Ensembl	P	neural crest cell development
GO:0001569	IEA:Ensembl	P	patterning of blood vessels
GO:0043084	IEA:Ensembl	P	penile erection
GO:0008284	IEA:Ensembl	P	positive regulation of cell proliferation
GO:0007204	TAS:ProtInc	P	positive regulation of cytosolic calcium ion concentration
GO:0051482	IEA:Ensembl	P	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
GO:0070374	IEA:Ensembl	P	positive regulation of ERK1 and ERK2 cascade
GO:0050729	IEA:Ensembl	P	positive regulation of inflammatory response
GO:0090184	IEA:Ensembl	P	positive regulation of kidney development
GO:0090023	IEA:Ensembl	P	positive regulation of neutrophil chemotaxis
GO:0042482	IEA:Ensembl	P	positive regulation of odontogenesis
GO:0001934	IEA:Ensembl	P	positive regulation of protein phosphorylation
GO:0051281	IEA:Ensembl	P	positive regulation of release of sequestered calcium ion into cytosol
GO:0007205	IEA:Ensembl	P	protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0008217	IEA:InterPro	P	regulation of blood pressure
GO:0050678	IEA:Ensembl	P	regulation of epithelial cell proliferation
GO:0007585	ISS:UniProtKB	P	respiratory gaseous exchange
GO:0001666	IEA:Ensembl	P	response to hypoxia
GO:0032496	IEA:Ensembl	P	response to lipopolysaccharide
GO:0043278	IEA:Ensembl	P	response to morphine
GO:0007266	IEA:Ensembl	P	Rho protein signal transduction
GO:0019233	IEA:Ensembl	P	sensory perception of pain
GO:0007165	TAS:ProtInc	P	signal transduction
GO:0048659	IEA:Ensembl	P	smooth muscle cell proliferation
GO:0006939	NAS:UniProtKB	P	smooth muscle contraction
GO:0042310	IMP:BHF-UCL	P	vasoconstriction

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_14828	Class A/1 (Rhodopsin-like receptors)
REACT_267874	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
REACT_116125	Disease
REACT_18283	G alpha (q) signalling events
REACT_120966	Gastrin-CREB signalling pathway via PKC and MAPK
REACT_19184	GPCR downstream signaling
REACT_21340	GPCR ligand binding
REACT_267615	Metabolic disorders of biological oxidation enzymes
REACT_14819	Peptide ligand-binding receptors
REACT_14797	Signaling by GPCR
REACT_111102	Signal Transduction