MGP Database

MGP000910

Ontology/Pathway Information

Entrez Gene ID	1910
Gene Name	endothelin receptor type B
Gene Symbol	EDNRB
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005887	TAS:ProtInc	C	integral component of plasma membrane
GO:0045121	IEA:Ensembl	C	membrane raft
GO:0031965	IEA:Ensembl	C	nuclear membrane
GO:0005886	TAS:Reactome	C	plasma membrane
GO:0004962	IDA:BHF-UCL	F	endothelin receptor activity
GO:0017046	IPI:BHF-UCL	F	peptide hormone binding
GO:0007568	IEA:Ensembl	P	aging
GO:0007166	TAS:ProtInc	P	cell surface receptor signaling pathway
GO:0071222	IEA:Ensembl	P	cellular response to lipopolysaccharide
GO:0019934	IEA:Ensembl	P	cGMP-mediated signaling
GO:0086100	IDA:GOC	P	endothelin receptor signaling pathway
GO:0048484	ISS:BHF-UCL	P	enteric nervous system development
GO:0035645	ISS:BHF-UCL	P	enteric smooth muscle cell differentiation
GO:0042045	IEA:Ensembl	P	epithelial fluid transport
GO:0048246	IMP:BHF-UCL	P	macrophage chemotaxis
GO:0030318	IEA:Ensembl	P	melanocyte differentiation
GO:0007194	TAS:ProtInc	P	negative regulation of adenylate cyclase activity
GO:0043066	IEA:Ensembl	P	negative regulation of apoptotic process
GO:0032269	IMP:BHF-UCL	P	negative regulation of cellular protein metabolic process
GO:0014043	ISS:BHF-UCL	P	negative regulation of neuron maturation
GO:0000122	IMP:BHF-UCL	P	negative regulation of transcription from RNA polymerase II promoter
GO:0007399	TAS:ProtInc	P	nervous system development
GO:0001755	IEA:Ensembl	P	neural crest cell migration
GO:0007422	IEA:Ensembl	P	peripheral nervous system development
GO:0007200	TAS:ProtInc	P	phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0008284	IEA:Ensembl	P	positive regulation of cell proliferation
GO:0007204	IEA:Ensembl	P	positive regulation of cytosolic calcium ion concentration
GO:0060406	IEA:Ensembl	P	positive regulation of penile erection
GO:0001934	IEA:Ensembl	P	positive regulation of protein phosphorylation
GO:0035815	IEA:Ensembl	P	positive regulation of renal sodium excretion
GO:0035810	IEA:Ensembl	P	positive regulation of urine volume
GO:0007497	IEA:Ensembl	P	posterior midgut development
GO:0008217	IEA:Ensembl	P	regulation of blood pressure
GO:0050678	IEA:Ensembl	P	regulation of epithelial cell proliferation
GO:0031620	IEA:Ensembl	P	regulation of fever generation
GO:0006885	IEA:Ensembl	P	regulation of pH
GO:0051930	IEA:Ensembl	P	regulation of sensory perception of pain
GO:0014070	IEA:Ensembl	P	response to organic cyclic compound
GO:0048265	IEA:Ensembl	P	response to pain
GO:0019233	IEA:Ensembl	P	sensory perception of pain
GO:0042310	IMP:BHF-UCL	P	vasoconstriction
GO:0042311	IEA:Ensembl	P	vasodilation
GO:0014826	IMP:BHF-UCL	P	vein smooth muscle contraction

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_14828	Class A/1 (Rhodopsin-like receptors)
REACT_267874	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
REACT_116125	Disease
REACT_18283	G alpha (q) signalling events
REACT_120966	Gastrin-CREB signalling pathway via PKC and MAPK
REACT_19184	GPCR downstream signaling
REACT_21340	GPCR ligand binding
REACT_267615	Metabolic disorders of biological oxidation enzymes
REACT_14819	Peptide ligand-binding receptors
REACT_14797	Signaling by GPCR
REACT_111102	Signal Transduction