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MGP000913

UniProt Annotations

Entry Information
Gene Nameeukaryotic translation elongation factor 1 alpha 1
Protein EntryEF1A1_HUMAN
UniProt IDP68104
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P68104-1; Sequence=Displayed; Name=2; IsoId=P68104-2; Sequence=VSP_057184; Note=No experimental confirmation available.;
FunctionThis protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. With PARP1 and TXK, forms a complex that acts as a T helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production. {ECO:0000269|PubMed:17177976}.
InductionBy homocysteine (HC), may mediate accelerated synthesis of free thiol-containing proteins in response to HC-induced oxidative stress. {ECO:0000269|PubMed:9677419}.
InteractionQ8NFJ9:BBS1; NbExp=3; IntAct=EBI-352162, EBI-1805484; Q00987:MDM2; NbExp=9; IntAct=EBI-352162, EBI-389668; P54725:RAD23A; NbExp=2; IntAct=EBI-352162, EBI-746453; Q9NYA1:SPHK1; NbExp=2; IntAct=EBI-352162, EBI-985303; P63104:YWHAZ; NbExp=2; IntAct=EBI-352162, EBI-347088; Q05516:ZBTB16; NbExp=4; IntAct=EBI-352162, EBI-711925; Q8IUH5:ZDHHC17; NbExp=2; IntAct=EBI-352162, EBI-524753;
PtmISGylated. {ECO:0000269|PubMed:16139798}.
PtmPhosphorylated by TXK. Phosphorylation by PASK increases translation efficiency. {ECO:0000269|PubMed:17177976, ECO:0000269|PubMed:17595531, ECO:0000269|PubMed:20832312}.
Sequence CautionSequence=AAA52367.1; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily. {ECO:0000305}.
SimilarityContains 1 tr-type G (guanine nucleotide-binding) domain. {ECO:0000305}.
Subcellular LocationCytoplasm. Nucleus. Nucleus, nucleolus. Note=Colocalizes with DLC1 at actin-rich regions in the cell periphery. Translocates together with ZPR1 from the cytoplasm to the nucleus and nucleolus after treatment with mitogens.
SubunitFound in a nuclear export complex with XPO5, EEF1A1, Ran and aminoacylated tRNA. Interacts with PARP1, TXK, XPO5 and KARS. May interact with ERGIC2. Interacts with IFIT1 (via TPR repeats 4- 7) (By similarity). Interacts with DLC1, facilitating distribution to the membrane periphery and ruffles upon growth factor stimulation. Interacts with ZPR1; the interaction occurs in a epidermal growth factor (EGF)-dependent manner. {ECO:0000250, ECO:0000269|PubMed:12426392, ECO:0000269|PubMed:12426393, ECO:0000269|PubMed:17177976, ECO:0000269|PubMed:17980171, ECO:0000269|PubMed:18029264, ECO:0000269|PubMed:19158340, ECO:0000269|PubMed:8650580}.
Tissue SpecificityBrain, placenta, lung, liver, kidney, pancreas but barely detectable in heart and skeletal muscle.
Web ResourceName=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/EEF1A1ID40407ch6q13.html";
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