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MGP000925

Record overview

MGPD IDMGP000925
Gene ID1948
SpeciesHomo sapiens (Human)
Gene Nameephrin-B2
Gene Symbol EFNB2
SynonymsHTKL; EPLG5; Htk-L; LERK5;
Alternate namesephrin-B2; LERK-5; HTK ligand; ligand of eph-related kinase 5; eph-related receptor tyrosine kinase ligand 5;
Chromosome13
Map Location13q33
SummaryThis gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNB class ephrin which binds to the EPHB4 and EPHA3 receptors. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for EFNB2

Proteins

ephrin-B2 precursor
Refseq ID:NP_004084
Protein GI:4758250
UniProt ID:P52799
mRNA ID:NM_004093
Length:333
RefSeq Status:
MAVRRDSVWKYCWGVLMVLCRTAISKSIVLEPIYWNSSNSKFLPGQGLVLYPQIGDKLDIICPKVDSKTVGQYEYYKVYMVDKDQADRCTIKKENTPLLN
CAKPDQDIKFTIKFQEFSPNLWGLEFQKNKDYYIISTSNGSLEGLDNQEGGVCQTRAMKILMKVGQDASSAGSTRNKDPTRRPELEAGTNGRSSTTSPFV
KPNPGSSTDGNSAGHSGNNILGSEVALFAGIASGCIIFIVIIITLVVLLLKYRRRHRKHSPQHTTTLSLSTLATPKRSGNNNGSEPSDIIIPLRTADSVF
CPHYEKVSGDYGHPVYIVQEMPPQSPANIYYKV
 
sig_peptide: 1..27
inference: non-experimental evidence, no additional details recorded
note: Potential; propagated from UniProtKB/Swiss-Prot (P52799.1)
calculated_mol_wt: 3160
peptide sequence: 
MAVRRDSVWKYCWGVLMVLCRTAISKS

mat_peptide: 28..333
product: Ephrin-B2
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P52799.1)
calculated_mol_wt: 33782
peptide sequence: 
IVLEPIYWNSSNSKFLPGQGLVLYPQIGDKLDIICPKVDSKTVGQYEYYKVYMVDKDQADRCTIKKENTPLLNCAKPDQDIKFTIKFQEFSPNLWGLEFQ
KNKDYYIISTSNGSLEGLDNQEGGVCQTRAMKILMKVGQDASSAGSTRNKDPTRRPELEAGTNGRSSTTSPFVKPNPGSSTDGNSAGHSGNNILGSEVAL
FAGIASGCIIFIVIIITLVVLLLKYRRRHRKHSPQHTTTLSLSTLATPKRSGNNNGSEPSDIIIPLRTADSVFCPHYEKVSGDYGHPVYIVQEMPPQSPA
NIYYKV
 
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