MGP Database

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MGP000928

Ontology/Pathway Information

Entrez Gene ID1956
Gene Nameepidermal growth factor receptor
Gene Symbol EGFR
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0016324 IEA:EnsemblCapical plasma membrane
GO:0016323 IDA:BHF-UCLCbasolateral plasma membrane
GO:0009986 IEA:EnsemblCcell surface
GO:0005737 IDA:UniProtKBCcytoplasm
GO:0030139 IEA:EnsemblCendocytic vesicle
GO:0005789 IEA:UniProtKB-SubCellCendoplasmic reticulum membrane
GO:0005768 IDA:UniProtKBCendosome
GO:0010008 IDA:UniProtKBCendosome membrane
GO:0005615 NAS:UniProtKBCextracellular space
GO:0005925 IDA:UniProtKBCfocal adhesion
GO:0000139 IEA:UniProtKB-SubCellCGolgi membrane
GO:0016021 IEA:UniProtKB-KWCintegral component of membrane
GO:0016020 IDA:UniProtKBCmembrane
GO:0045121 IDA:UniProtKBCmembrane raft
GO:0031965 IEA:UniProtKB-SubCellCnuclear membrane
GO:0005634 IDA:UniProtKBCnucleus
GO:0048471 IEA:EnsemblCperinuclear region of cytoplasm
GO:0005886 IDA:HGNCCplasma membrane
GO:0043235 IDA:MGICreceptor complex
GO:0070435 ISS:BHF-UCLCShc-EGFR complex
GO:0051015 IDA:UniProtKBFactin filament binding
GO:0005524 IEA:UniProtKB-KWFATP binding
GO:0003682 IDA:UniProtKBFchromatin binding
GO:0003690 NAS:UniProtKBFdouble-stranded DNA binding
GO:0019899 IPI:UniProtKBFenzyme binding
GO:0005006 IDA:UniProtKBFepidermal growth factor-activated receptor activity
GO:0042802 IPI:IntActFidentical protein binding
GO:0004709 NAS:UniProtKBFMAP kinase kinase kinase activity
GO:0046982 IDA:UniProtKBFprotein heterodimerization activity
GO:0019903 IPI:UniProtKBFprotein phosphatase binding
GO:0004713 IDA:UniProtKBFprotein tyrosine kinase activity
GO:0004716 IEA:InterProFreceptor signaling protein tyrosine kinase activity
GO:0004714 TAS:ReactomeFtransmembrane receptor protein tyrosine kinase activity
GO:0004888 IDA:MGIFtransmembrane signaling receptor activity
GO:0031625 IPI:UniProtKBFubiquitin protein ligase binding
GO:0043006 TAS:UniProtKBPactivation of phospholipase A2 activity by calcium-mediated signaling
GO:0007202 TAS:UniProtKBPactivation of phospholipase C activity
GO:0019694 IEA:EnsemblPalkanesulfonate metabolic process
GO:0048143 IEA:EnsemblPastrocyte activation
GO:0007411 TAS:ReactomePaxon guidance
GO:0008283 IDA:UniProtKBPcell proliferation
GO:0007166 IDA:MGIPcell surface receptor signaling pathway
GO:0071230 IEA:EnsemblPcellular response to amino acid stimulus
GO:0071549 IEA:EnsemblPcellular response to dexamethasone stimulus
GO:0035690 IEA:EnsemblPcellular response to drug
GO:0071364 ISS:UniProtKBPcellular response to epidermal growth factor stimulus
GO:0071392 IDA:UniProtKBPcellular response to estradiol stimulus
GO:0071260 IEA:EnsemblPcellular response to mechanical stimulus
GO:0021795 IEA:EnsemblPcerebral cortex cell migration
GO:0007623 IEA:EnsemblPcircadian rhythm
GO:0048546 IEA:EnsemblPdigestive tract morphogenesis
GO:0016101 IEA:EnsemblPditerpenoid metabolic process
GO:0001892 IEA:EnsemblPembryonic placenta development
GO:0007173 IDA:UniProtKBPepidermal growth factor receptor signaling pathway
GO:0038095 TAS:ReactomePFc-epsilon receptor signaling pathway
GO:0008543 TAS:ReactomePfibroblast growth factor receptor signaling pathway
GO:0001942 IEA:EnsemblPhair follicle development
GO:0042743 IEA:EnsemblPhydrogen peroxide metabolic process
GO:0045087 TAS:ReactomePinnate immune response
GO:0007611 ISS:UniProtKBPlearning or memory
GO:0001889 IEA:EnsemblPliver development
GO:0030324 IEA:EnsemblPlung development
GO:0010960 IEA:EnsemblPmagnesium ion homeostasis
GO:0000165 NAS:GOCPMAPK cascade
GO:0060571 IEA:EnsemblPmorphogenesis of an epithelial fold
GO:0043066 IMP:UniProtKBPnegative regulation of apoptotic process
GO:0042059 TAS:ReactomePnegative regulation of epidermal growth factor receptor signaling pathway
GO:0045930 IEA:EnsemblPnegative regulation of mitotic cell cycle
GO:0042177 IDA:UniProtKBPnegative regulation of protein catabolic process
GO:0048011 TAS:ReactomePneurotrophin TRK receptor signaling pathway
GO:0001503 NAS:UniProtKBPossification
GO:0042698 IEA:EnsemblPovulation cycle
GO:0018108 IDA:GOCPpeptidyl-tyrosine phosphorylation
GO:0048015 TAS:ReactomePphosphatidylinositol-mediated signaling
GO:0035413 IMP:BHF-UCLPpositive regulation of catenin import into nucleus
GO:0030335 IMP:UniProtKBPpositive regulation of cell migration
GO:0008284 IDA:MGIPpositive regulation of cell proliferation
GO:0031659 IDA:BHF-UCLPpositive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
GO:0045739 IDA:UniProtKBPpositive regulation of DNA repair
GO:0045740 IDA:UniProtKBPpositive regulation of DNA replication
GO:0050679 IDA:UniProtKBPpositive regulation of epithelial cell proliferation
GO:0070374 IDA:UniProtKBPpositive regulation of ERK1 and ERK2 cascade
GO:0048146 IEA:EnsemblPpositive regulation of fibroblast proliferation
GO:0050729 IEA:EnsemblPpositive regulation of inflammatory response
GO:0043406 IDA:UniProtKBPpositive regulation of MAP kinase activity
GO:0045429 IDA:UniProtKBPpositive regulation of nitric oxide biosynthetic process
GO:0042327 IDA:UniProtKBPpositive regulation of phosphorylation
GO:0051897 IMP:BHF-UCLPpositive regulation of protein kinase B signaling
GO:0001934 IDA:UniProtKBPpositive regulation of protein phosphorylation
GO:0048661 IEA:EnsemblPpositive regulation of smooth muscle cell proliferation
GO:0032930 IEA:EnsemblPpositive regulation of superoxide anion generation
GO:0051968 IEA:EnsemblPpositive regulation of synaptic transmission, glutamatergic
GO:0045944 IDA:UniProtKBPpositive regulation of transcription from RNA polymerase II promoter
GO:0045907 IEA:EnsemblPpositive regulation of vasoconstriction
GO:0045909 IEA:EnsemblPpositive regulation of vasodilation
GO:0046777 IMP:UniProtKBPprotein autophosphorylation
GO:0051205 TAS:UniProtKBPprotein insertion into membrane
GO:0050999 IDA:UniProtKBPregulation of nitric-oxide synthase activity
GO:0050730 IMP:UniProtKBPregulation of peptidyl-tyrosine phosphorylation
GO:0051592 IEA:EnsemblPresponse to calcium ion
GO:0033590 IEA:EnsemblPresponse to cobalamin
GO:0033594 IEA:EnsemblPresponse to hydroxyisoflavone
GO:0006970 IEA:EnsemblPresponse to osmotic stress
GO:0006979 IEA:EnsemblPresponse to oxidative stress
GO:0006950 NAS:UniProtKBPresponse to stress
GO:0070141 IDA:BHF-UCLPresponse to UV-A
GO:0007435 IEA:EnsemblPsalivary gland morphogenesis
GO:0007165 IDA:UniProtKBPsignal transduction
GO:0016337 IMP:UniProtKBPsingle organismal cell-cell adhesion
GO:0043586 IEA:EnsemblPtongue development
GO:0006412 IEA:EnsemblPtranslation
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_75774Adaptive Immune System
REACT_18266Axon guidance
REACT_147727Constitutive PI3K/AKT Signaling in Cancer
REACT_267817Constitutive Signaling by EGFRvIII
REACT_115852Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
REACT_147694DAP12 interactions
REACT_147814DAP12 signaling
REACT_111045Developmental Biology
REACT_116125Disease
REACT_118638Downstream signaling events of B Cell Receptor (BCR)
REACT_21272Downstream signaling of activated FGFR
REACT_17025Downstream signal transduction
REACT_12484EGFR downregulation
REACT_12478EGFR interacts with phospholipase C-gamma
REACT_121096EGFR Transactivation by Gastrin
REACT_163936Fc epsilon receptor (FCERI) signaling
REACT_12578GAB1 signalosome
REACT_120966Gastrin-CREB signalling pathway via PKC and MAPK
REACT_12606GRB2 events in EGFR signaling
REACT_115854GRB2 events in ERBB2 signaling
REACT_6900Immune System
REACT_268595Inhibition of Signaling by Overexpressed EGFR
REACT_6802Innate Immune System
REACT_22205L1CAM interactions
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_12464PI3K/AKT activation
REACT_147723PI3K/AKT Signaling in Cancer
REACT_21270PI-3K cascade
REACT_116008PI3K events in ERBB2 signaling
REACT_115961PI3K events in ERBB4 signaling
REACT_75829PIP3 activates AKT signaling
REACT_115720PLCG1 events in ERBB2 signaling
REACT_163769Role of LAT2/NTAL/LAB on calcium mobilization
REACT_12579SHC1 events in EGFR signaling
REACT_115993SHC1 events in ERBB2 signaling
REACT_9417Signaling by EGFR
REACT_115871Signaling by EGFR in Cancer
REACT_268269Signaling by EGFRvIII in Cancer
REACT_115755Signaling by ERBB2
REACT_115596Signaling by ERBB4
REACT_9470Signaling by FGFR
REACT_120736Signaling by FGFR in disease
REACT_14797Signaling by GPCR
REACT_268006Signaling by Ligand-Responsive EGFR Variants in Cancer
REACT_268546Signaling by Overexpressed Wild-Type EGFR in Cancer
REACT_16888Signaling by PDGF
REACT_111040Signaling by SCF-KIT
REACT_118773Signaling by the B Cell Receptor (BCR)
REACT_11061Signalling by NGF
REACT_111102Signal Transduction
REACT_22272Signal transduction by L1
SMP Pathway Links
SMP IDDescription
SMP00474Cetuximab Action Pathway
SMP00472Erlotinib Action Pathway
SMP00473Gefitinib Action Pathway
SMP00475Panitumumab Action Pathway
SMP00476Trastuzumab Action Pathway
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