MGP Database

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MGP000930

Record overview

MGPD IDMGP000930
Gene ID1959
SpeciesHomo sapiens (Human)
Gene Nameearly growth response 2
Gene Symbol EGR2
SynonymsAT591; CMT1D; CMT4E; KROX20;
Alternate namesE3 SUMO-protein ligase EGR2; zinc finger protein Krox-20; early growth response protein 2; KROX-20, Drosophila, homolog (early growth response-2);
Chromosome10
Map Location10q21.1
EC Number6.3.2.-
SummaryThe protein encoded by this gene is a transcription factor with three tandem C2H2-type zinc fingers. Defects in this gene are associated with Charcot-Marie-Tooth disease type 1D (CMT1D), Charcot-Marie-Tooth disease type 4E (CMT4E), and with Dejerine-Sottas syndrome (DSS). Multiple transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
OrthologsView orthologs and multiple alignments for EGR2

Proteins

E3 SUMO-protein ligase EGR2 isoform a
Refseq ID:NP_001129649
Protein GI:209969753
UniProt ID:P11161
mRNA ID:NM_001136177
Length:476
RefSeq Status:
MMTAKAVDKIPVTLSGFVHQLSDNIYPVEDLAATSVTIFPNAELGGPFDQMNGVAGDGMINIDMTGEKRSLDLPYPSSFAPVSAPRNQTFTYMGKFSIDP
QYPGASCYPEGIINIVSAGILQGVTSPASTTASSSVTSASPNPLATGPLGVCTMSQTQPDLDHLYSPPPPPPPYSGCAGDLYQDPSAFLSAATTSTSSSL
AYPPPPSYPSPKPATDPGLFPMIPDYPGFFPSQCQRDLHGTAGPDRKPFPCPLDTLRVPPPLTPLSTIRNFTLGGPSAGVTGPGASGGSEGPRLPGSSSA
AAAAAAAAAYNPHHLPLRPILRPRKYPNRPSKTPVHERPYPCPAEGCDRRFSRSDELTRHIRIHTGHKPFQCRICMRNFSRSDHLTTHIRTHTGEKPFAC
DYCGRKFARSDERKRHTKIHLRQKERKSSAPSASVPAPSTASCSGGVQPGGTLCSSNSSSLGGGPLAPCSSRTRTP
 
E3 SUMO-protein ligase EGR2 isoform a
Refseq ID:NP_000390
Protein GI:9845524
UniProt ID:P11161
mRNA ID:NM_000399
Length:476
RefSeq Status:
Protein sequence is identical to GI:209969753 (mRNA isoform)
 
E3 SUMO-protein ligase EGR2 isoform a
Refseq ID:NP_001129650
Protein GI:209969755
UniProt ID:P11161
mRNA ID:NM_001136178
Length:476
RefSeq Status:
Protein sequence is identical to GI:209969753 (mRNA isoform)
 
E3 SUMO-protein ligase EGR2 isoform b
Refseq ID:NP_001129651
Protein GI:209969757
UniProt ID:P11161
mRNA ID:NM_001136179
Length:426
RefSeq Status:
MNGVAGDGMINIDMTGEKRSLDLPYPSSFAPVSAPRNQTFTYMGKFSIDPQYPGASCYPEGIINIVSAGILQGVTSPASTTASSSVTSASPNPLATGPLG
VCTMSQTQPDLDHLYSPPPPPPPYSGCAGDLYQDPSAFLSAATTSTSSSLAYPPPPSYPSPKPATDPGLFPMIPDYPGFFPSQCQRDLHGTAGPDRKPFP
CPLDTLRVPPPLTPLSTIRNFTLGGPSAGVTGPGASGGSEGPRLPGSSSAAAAAAAAAAYNPHHLPLRPILRPRKYPNRPSKTPVHERPYPCPAEGCDRR
FSRSDELTRHIRIHTGHKPFQCRICMRNFSRSDHLTTHIRTHTGEKPFACDYCGRKFARSDERKRHTKIHLRQKERKSSAPSASVPAPSTASCSGGVQPG
GTLCSSNSSSLGGGPLAPCSSRTRTP
 
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