MGP Database

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MGP000945

UniProt Annotations

Entry Information
Gene Nameeukaryotic translation initiation factor 5A
Protein EntryIF5A1_HUMAN
UniProt IDP63241
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; Synonyms=B, C, D; IsoId=P63241-1; Sequence=Displayed; Name=2; Synonyms=A; IsoId=P63241-2; Sequence=VSP_022020;
BiotechnologyMature eIF5A-1 may be used as an in situ diagnostic marker for aberrant proliferation in intraepithelial neoplasia of the vulva. {ECO:0000269|PubMed:15262146}.
FunctionmRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. With syntenin SDCBP, functions as a regulator of p53/TP53 and p53/TP53-dependent apoptosis. Regulates also TNF- alpha-mediated apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation. Also described as a cellular cofactor of human T-cell leukemia virus type I (HTLV-1) Rex protein and of human immunodeficiency virus type 1 (HIV-1) Rev protein, essential for mRNA export of retroviral transcripts. {ECO:0000269|PubMed:15371445, ECO:0000269|PubMed:15452064, ECO:0000269|PubMed:16987817, ECO:0000269|PubMed:17187778, ECO:0000269|PubMed:17360499}.
PtmAcetylated. Deacetylated by SIRT2. {ECO:0000269|PubMed:19379712, ECO:0000269|PubMed:22771473, ECO:0000269|Ref.10}.
PtmeIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group (from spermidine).
SimilarityBelongs to the eIF-5A family. {ECO:0000305}.
Subcellular LocationCytoplasm. Nucleus. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus, nuclear pore complex. Note=Hypusine modification promotes the nuclear export and cytoplasmic localization and there was a dynamic shift in the localization from predominantly cytoplasmic to primarily nuclear under apoptotic inducing conditions.
SubunitInteracts with DHPS, with SDCBP and DOHH. Interacts with HIV-1 protein Rev. Found in a complex with Ran and XPO4. The hypusine modification increases the interaction with XPO4. {ECO:0000269|PubMed:10229683, ECO:0000269|PubMed:10944119, ECO:0000269|PubMed:15371445, ECO:0000269|PubMed:17213197, ECO:0000269|PubMed:8253832}.
Tissue SpecificityExpressed in umbilical vein endothelial cells and several cancer cell lines (at protein level). {ECO:0000269|PubMed:16519677}.
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