MGP Database

MGP000946

Ontology/Pathway Information

Entrez Gene ID	1991
Gene Name	elastase, neutrophil expressed
Gene Symbol	ELANE
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0009986	IDA:UniProtKB	C	cell surface
GO:0005737	IDA:UniProtKB	C	cytoplasm
GO:0005576	NAS:UniProtKB	C	extracellular region
GO:0070062	IDA:UniProtKB	C	extracellular vesicular exosome
GO:0030141	IDA:MGI	C	secretory granule
GO:0017053	IDA:UniProtKB	C	transcriptional repressor complex
GO:0019955	IPI:UniProtKB	F	cytokine binding
GO:0004175	IDA:UniProtKB	F	endopeptidase activity
GO:0008201	IDA:MGI	F	heparin binding
GO:0008233	IDA:MGI	F	peptidase activity
GO:0002020	IPI:BHF-UCL	F	protease binding
GO:0001106	IMP:UniProtKB	F	RNA polymerase II transcription corepressor activity
GO:0004252	IEA:Ensembl	F	serine-type endopeptidase activity
GO:0002438	IEA:Ensembl	P	acute inflammatory response to antigenic stimulus
GO:0006874	NAS:UniProtKB	P	cellular calcium ion homeostasis
GO:0030574	TAS:Reactome	P	collagen catabolic process
GO:0042742	IDA:UniProtKB	P	defense response to bacterium
GO:0022617	TAS:Reactome	P	extracellular matrix disassembly
GO:0030198	TAS:Reactome	P	extracellular matrix organization
GO:0050900	IEA:Ensembl	P	leukocyte migration
GO:0045079	IDA:UniProtKB	P	negative regulation of chemokine biosynthetic process
GO:0050922	NAS:UniProtKB	P	negative regulation of chemotaxis
GO:0044130	IEA:Ensembl	P	negative regulation of growth of symbiont in host
GO:0050728	NAS:UniProtKB	P	negative regulation of inflammatory response
GO:0045415	IDA:UniProtKB	P	negative regulation of interleukin-8 biosynthetic process
GO:0000122	IMP:UniProtKB	P	negative regulation of transcription from RNA polymerase II promoter
GO:0070947	IEA:Ensembl	P	neutrophil mediated killing of fungus
GO:0006909	IEA:Ensembl	P	phagocytosis
GO:0050778	IEA:Ensembl	P	positive regulation of immune response
GO:0045416	IDA:UniProtKB	P	positive regulation of interleukin-8 biosynthetic process
GO:0043406	NAS:UniProtKB	P	positive regulation of MAP kinase activity
GO:0048661	IDA:UniProtKB	P	positive regulation of smooth muscle cell proliferation
GO:0030163	NAS:UniProtKB	P	protein catabolic process
GO:0006508	IDA:MGI	P	proteolysis
GO:0032496	IEA:Ensembl	P	response to lipopolysaccharide
GO:0009411	IDA:UniProtKB	P	response to UV
GO:0001878	IEA:Ensembl	P	response to yeast

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_118682	Activation of Matrix Metalloproteinases
REACT_150401	Collagen degradation
REACT_118572	Degradation of the extracellular matrix
REACT_118779	Extracellular matrix organization