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MGP000953

UniProt Annotations

Entry Information
Gene Nameenolase 2 (gamma, neuronal)
Protein EntryENOG_HUMAN
UniProt IDP09104
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P09104-1; Sequence=Displayed; Name=2; IsoId=P09104-2; Sequence=VSP_055482; Note=No experimental confirmation available.;
Catalytic Activity2-phospho-D-glycerate = phosphoenolpyruvate + H(2)O.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Mg(2+) is required for catalysis and for stabilizing the dimer.;
Developmental StageDuring ontogenesis, there is a transition from the alpha/alpha homodimer to the alpha/beta heterodimer in striated muscle cells, and to the alpha/gamma heterodimer in nerve cells.
FunctionHas neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival (By similarity). {ECO:0000250}.
InductionLevels of ENO2 increase dramatically in cardiovascular accidents, cerebral trauma, brain tumors and Creutzfeldt-Jakob disease.
PathwayCarbohydrate degradation; glycolysis; pyruvate from D- glyceraldehyde 3-phosphate: step 4/5.
Sequence CautionSequence=AAA52388.1; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the enolase family. {ECO:0000305}.
Subcellular LocationCytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Can translocate to the plasma membrane in either the homodimeric (alpha/alpha) or heterodimeric (alpha/gamma) form. {ECO:0000250}.
SubunitMammalian enolase is composed of 3 isozyme subunits, alpha, beta and gamma, which can form homodimers or heterodimers which are cell-type and development-specific. {ECO:0000269|PubMed:15289101}.
Tissue SpecificityThe alpha/alpha homodimer is expressed in embryo and in most adult tissues. The alpha/beta heterodimer and the beta/beta homodimer are found in striated muscle, and the alpha/gamma heterodimer and the gamma/gamma homodimer in neurons.
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