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MGP000954

Record overview

MGPD IDMGP000954
Gene ID2027
SpeciesHomo sapiens (Human)
Gene Nameenolase 3 (beta, muscle)
Gene Symbol ENO3
SynonymsMSE; GSD13;
Alternate namesbeta-enolase; 2-phospho-D-glycerate hydrolyase; muscle-specific enolase; skeletal muscle enolase;
Chromosome17
Map Location17p13.2
EC Number4.2.1.11
SummaryThis gene encodes one of the three enolase isoenzymes found in mammals. This isoenzyme is found in skeletal muscle cells in the adult where it may play a role in muscle development and regeneration. A switch from alpha enolase to beta enolase occurs in muscle tissue during development in rodents. Mutations in this gene have be associated glycogen storage disease. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Jul 2010]
OrthologsView orthologs and multiple alignments for ENO3

Proteins

beta-enolase isoform 1
Refseq ID:NP_001967
Protein GI:301897469
UniProt ID:P13929
mRNA ID:NM_001976
Length:434
RefSeq Status:
MAMQKIFAREILDSRGNPTVEVDLHTAKGRFRAAVPSGASTGIYEALELRDGDKGRYLGKGVLKAVENINNTLGPALLQKKLSVVDQEKVDKFMIELDGT
ENKSKFGANAILGVSLAVCKAGAAEKGVPLYRHIADLAGNPDLILPVPAFNVINGGSHAGNKLAMQEFMILPVGASSFKEAMRIGAEVYHHLKGVIKAKY
GKDATNVGDEGGFAPNILENNEALELLKTAIQAAGYPDKVVIGMDVAASEFYRNGKYDLDFKSPDDPARHITGEKLGELYKSFIKNYPVVSIEDPFDQDD
WATWTSFLSGVNIQIVGDDLTVTNPKRIAQAVEKKACNCLLLKVNQIGSVTESIQACKLAQSNGWGVMVSHRSGETEDTFIADLVVGLCTGQIKTGAPCR
SERLAKYNQLMRIEEALGDKAIFAGRKFRNPKAK
 
beta-enolase isoform 1
Refseq ID:NP_443739
Protein GI:301897477
UniProt ID:P13929
mRNA ID:NM_053013
Length:434
RefSeq Status:
Protein sequence is identical to GI:301897469 (mRNA isoform)
 
beta-enolase isoform 2
Refseq ID:NP_001180432
Protein GI:301897479
UniProt ID:P13929
mRNA ID:NM_001193503
Length:391
RefSeq Status:
MAMQKIFAREILDSRGNPTVEVDLHTAKGRFRAAVPSGASTGIYEALELRDGDKGRYLGKAKFGANAILGVSLAVCKAGAAEKGVPLYRHIADLAGNPDL
ILPVPAFNVINGGSHAGNKLAMQEFMILPVGASSFKEAMRIGAEVYHHLKGVIKAKYGKDATNVGDEGGFAPNILENNEALELLKTAIQAAGYPDKVVIG
MDVAASEFYRNGKYDLDFKSPDDPARHITGEKLGELYKSFIKNYPVVSIEDPFDQDDWATWTSFLSGVNIQIVGDDLTVTNPKRIAQAVEKKACNCLLLK
VNQIGSVTESIQACKLAQSNGWGVMVSHRSGETEDTFIADLVVGLCTGQIKTGAPCRSERLAKYNQLMRIEEALGDKAIFAGRKFRNPKAK
 
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