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MGP000955

UniProt Annotations

Entry Information
Gene Nameglutamyl aminopeptidase (aminopeptidase A)
Protein EntryAMPE_HUMAN
UniProt IDQ07075
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityRelease of N-terminal glutamate (and to a lesser extent aspartate) from a peptide.
CofactorName=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250}; Note=Binds 1 zinc ion per subunit. {ECO:0000250};
FunctionAppears to have a role in the catabolic pathway of the renin-angiotensin system. Probably plays a role in regulating growth and differentiation of early B-lineage cells.
SimilarityBelongs to the peptidase M1 family. {ECO:0000305}.
Subcellular LocationMembrane; Single-pass type II membrane protein.
SubunitHomodimer; disulfide-linked.
Tissue SpecificityExpressed by epithelial cells of the proximal tubule cells and the glomerulus of the nephron. Also found in a variety of other tissues.
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