MGP Database

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MGP000957

UniProt Annotations

Entry Information
Gene Namesolute carrier family 29 (equilibrative nucleoside transporter), member 1
Protein Entry
UniProt ID
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q99808-1; Sequence=Displayed; Name=2; IsoId=Q99808-2; Sequence=VSP_056579; Note=No experimental confirmation available.;
Biophysicochemical PropertiesKinetic parameters: KM=0.62 mM for adenosine {ECO:0000269|PubMed:12527552}; Note=Vmax for adenosine uptake is about the same for SLC29A1 and SLC29A2.;
FunctionMediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). It is sensitive (ES) to low concentrations of the inhibitor nitrobenzylmercaptopurine riboside (NBMPR) and is sodium-independent. It has a higher affinity for adenosine. Inhibited by dipyridamole and dilazep (anticancer chemotherapeutics drugs).
InteractionP49842:STK19; NbExp=1; IntAct=EBI-347907, EBI-347581;
PtmGlycosylated. {ECO:0000269|PubMed:19349973}.
SimilarityBelongs to the SLC29A/ENT transporter (TC 2.A.57) family. {ECO:0000305}.
Subcellular LocationBasolateral cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Predominantly localized in the basolateral membrane in polarized MDCK cells.
SubunitIdentified in a complex with STOM. {ECO:0000269|PubMed:23219802}.
Tissue SpecificityDetected in erythrocytes (at protein level). Expressed in heart, brain, mammary gland, erythrocytes and placenta, and also in fetal liver and spleen. {ECO:0000269|PubMed:12527552, ECO:0000269|PubMed:23219802}.
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