MGP Database

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MGP000959

Ontology/Pathway Information

Entrez Gene ID2034
Gene Nameendothelial PAS domain protein 1
Gene Symbol EPAS1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005829 TAS:ReactomeCcytosol
GO:0005654 TAS:ReactomeCnucleoplasm
GO:0005667 IDA:MGICtranscription factor complex
GO:0003677 IGI:MGIFDNA binding
GO:0035035 IPI:UniProtKBFhistone acetyltransferase binding
GO:0046982 IPI:BHF-UCLFprotein heterodimerization activity
GO:0001077 IEA:EnsemblFRNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0004871 IEA:InterProFsignal transducer activity
GO:0008134 IPI:BHF-UCLFtranscription factor binding
GO:0001525 IEA:UniProtKB-KWPangiogenesis
GO:0001974 IEA:EnsemblPblood vessel remodeling
GO:0048469 IEA:EnsemblPcell maturation
GO:0071456 IDA:UniProtKBPcellular response to hypoxia
GO:0001892 IEA:EnsemblPembryonic placenta development
GO:0030218 IEA:EnsemblPerythrocyte differentiation
GO:0030324 IEA:EnsemblPlung development
GO:0007005 IEA:EnsemblPmitochondrion organization
GO:0048625 ISS:BHF-UCLPmyoblast fate commitment
GO:0042415 IEA:EnsemblPnorepinephrine metabolic process
GO:0045944 IDA:UniProtKBPpositive regulation of transcription from RNA polymerase II promoter
GO:0002027 IEA:EnsemblPregulation of heart rate
GO:0061418 TAS:ReactomePregulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0043619 IEA:EnsemblPregulation of transcription from RNA polymerase II promoter in response to oxidative stress
GO:0001666 IDA:MGIPresponse to hypoxia
GO:0007165 TAS:ProtIncPsignal transduction
GO:0043129 IEA:EnsemblPsurfactant homeostasis
GO:0006366 TAS:ProtIncPtranscription from RNA polymerase II promoter
GO:0007601 IEA:EnsemblPvisual perception
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_120956Cellular responses to stress
REACT_121311Cellular response to hypoxia
REACT_111045Developmental Biology
REACT_121226Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha
REACT_120916Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
REACT_121092Regulation of gene expression by Hypoxia-inducible Factor
REACT_120815Regulation of Hypoxia-inducible Factor (HIF) by oxygen
REACT_263856Transcriptional regulation of pluripotent stem cells
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