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MGP000972

Record overview

MGPD IDMGP000972
Gene ID2052
SpeciesHomo sapiens (Human)
Gene Nameepoxide hydrolase 1, microsomal (xenobiotic)
Gene Symbol EPHX1
SynonymsMEH; EPHX; EPOX; HYL1;
Alternate namesepoxide hydrolase 1; epoxide hydratase;
Chromosome1
Map Location1q42.1
EC Number3.3.2.9
SummaryEpoxide hydrolase is a critical biotransformation enzyme that converts epoxides from the degradation of aromatic compounds to trans-dihydrodiols which can be conjugated and excreted from the body. Epoxide hydrolase functions in both the activation and detoxification of epoxides. Mutations in this gene cause preeclampsia, epoxide hydrolase deficiency or increased epoxide hydrolase activity. Alternatively spliced transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Dec 2008]
OrthologsView orthologs and multiple alignments for EPHX1

Proteins

epoxide hydrolase 1
Refseq ID:NP_001129490
Protein GI:209862837
UniProt ID:P07099
mRNA ID:NM_001136018
Length:455
RefSeq Status:
MWLEILLTSVLGFAIYWFISRDKEETLPLEDGWWGPGTRSAAREDDSIRPFKVETSDEEIHDLHQRIDKFRFTPPLEDSCFHYGFNSNYLKKVISYWRNE
FDWKKQVEILNRYPHFKTKIEGLDIHFIHVKPPQLPAGHTPKPLLMVHGWPGSFYEFYKIIPLLTDPKNHGLSDEHVFEVICPSIPGYGFSEASSKKGFN
SVATARIFYKLMLRLGFQEFYIQGGDWGSLICTNMAQLVPSHVKGLHLNMALVLSNFSTLTLLLGQRFGRFLGLTERDVELLYPVKEKVFYSLMRESGYM
HIQCTKPDTVGSALNDSPVGLAAYILEKFSTWTNTEFRYLEDGGLERKFSLDDLLTNVMLYWTTGTIISSQRFYKENLGQGWMTQKHERMKVYVPTGFSA
FPFELLHTPEKWVRFKYPKLISYSYMVRGGHFAAFEEPELLAQDIRKFLSVLERQ
 
epoxide hydrolase 1
Refseq ID:NP_001278092
Protein GI:600971691
UniProt ID:P07099
mRNA ID:NM_001291163
Length:455
RefSeq Status:
Protein sequence is identical to GI:209862837 (mRNA isoform)
 
epoxide hydrolase 1
Refseq ID:NP_000111
Protein GI:4503583
UniProt ID:P07099
mRNA ID:NM_000120
Length:455
RefSeq Status:
Protein sequence is identical to GI:209862837 (mRNA isoform)
 
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