MGP Database

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MGP000978

Ontology/Pathway Information

Entrez Gene ID2064
Gene Nameerb-b2 receptor tyrosine kinase 2
Gene Symbol ERBB2
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0016324 IEA:EnsemblCapical plasma membrane
GO:0016323 IDA:BHF-UCLCbasolateral plasma membrane
GO:0005737 IDA:HPACcytoplasm
GO:0031410 IEA:EnsemblCcytoplasmic vesicle
GO:0010008 IDA:UniProtKBCendosome membrane
GO:0016021 NAS:UniProtKBCintegral component of membrane
GO:0005634 IDA:UniProtKBCnucleus
GO:0048471 IEA:UniProtKB-SubCellCperinuclear region of cytoplasm
GO:0005886 NAS:UniProtKBCplasma membrane
GO:0043235 IDA:BHF-UCLCreceptor complex
GO:0005524 IEA:UniProtKB-KWFATP binding
GO:0043125 TAS:ProtIncFErbB-3 class receptor binding
GO:0042802 IPI:IntActFidentical protein binding
GO:0008022 IPI:UniProtKBFprotein C-terminus binding
GO:0046983 NAS:UniProtKBFprotein dimerization activity
GO:0046982 IDA:UniProtKBFprotein heterodimerization activity
GO:0019903 IPI:UniProtKBFprotein phosphatase binding
GO:0004713 IDA:BHF-UCLFprotein tyrosine kinase activity
GO:0004716 TAS:ProtIncFreceptor signaling protein tyrosine kinase activity
GO:0001042 IDA:UniProtKBFRNA polymerase I core binding
GO:0004714 IDA:BHF-UCLFtransmembrane receptor protein tyrosine kinase activity
GO:0004888 IDA:BHF-UCLFtransmembrane signaling receptor activity
GO:0007411 TAS:ReactomePaxon guidance
GO:0008283 TAS:ProtIncPcell proliferation
GO:0007166 IDA:MGIPcell surface receptor signaling pathway
GO:0007167 TAS:ProtIncPenzyme linked receptor protein signaling pathway
GO:0007173 TAS:ReactomePepidermal growth factor receptor signaling pathway
GO:0038095 TAS:ReactomePFc-epsilon receptor signaling pathway
GO:0008543 TAS:ReactomePfibroblast growth factor receptor signaling pathway
GO:0007507 IEA:EnsemblPheart development
GO:0045087 TAS:ReactomePinnate immune response
GO:0008045 IEA:EnsemblPmotor neuron axon guidance
GO:0042552 IEA:EnsemblPmyelination
GO:0033088 IEA:EnsemblPnegative regulation of immature T cell proliferation in thymus
GO:0007528 IEA:EnsemblPneuromuscular junction development
GO:0048011 TAS:ReactomePneurotrophin TRK receptor signaling pathway
GO:0048709 IEA:EnsemblPoligodendrocyte differentiation
GO:0018108 IDA:GOCPpeptidyl-tyrosine phosphorylation
GO:0007422 IEA:EnsemblPperipheral nervous system development
GO:0014065 IDA:BHF-UCLPphosphatidylinositol 3-kinase signaling
GO:0048015 TAS:ReactomePphosphatidylinositol-mediated signaling
GO:0045785 IDA:BHF-UCLPpositive regulation of cell adhesion
GO:0030307 IMP:UniProtKBPpositive regulation of cell growth
GO:0050679 IDA:UniProtKBPpositive regulation of epithelial cell proliferation
GO:0043406 IDA:UniProtKBPpositive regulation of MAP kinase activity
GO:0001934 ISS:BHF-UCLPpositive regulation of protein phosphorylation
GO:0032321 ISS:BHF-UCLPpositive regulation of Rho GTPase activity
GO:0045945 IDA:UniProtKBPpositive regulation of transcription from RNA polymerase III promoter
GO:0045943 IMP:UniProtKBPpositive regulation of transcription from RNA polymerase I promoter
GO:0045727 IMP:UniProtKBPpositive regulation of translation
GO:0046777 IDA:BHF-UCLPprotein autophosphorylation
GO:0006468 TAS:ProtIncPprotein phosphorylation
GO:0045765 NAS:UniProtKBPregulation of angiogenesis
GO:0070372 IMP:UniProtKBPregulation of ERK1 and ERK2 cascade
GO:0032886 IDA:UniProtKBPregulation of microtubule-based process
GO:0007165 IDA:UniProtKBPsignal transduction
GO:0023014 TAS:GOCPsignal transduction by phosphorylation
GO:0006351 IEA:UniProtKB-KWPtranscription, DNA-templated
GO:0007169 IDA:BHF-UCLPtransmembrane receptor protein tyrosine kinase signaling pathway
GO:0042060 IDA:BHF-UCLPwound healing
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_75774Adaptive Immune System
REACT_18266Axon guidance
REACT_147727Constitutive PI3K/AKT Signaling in Cancer
REACT_147694DAP12 interactions
REACT_147814DAP12 signaling
REACT_111045Developmental Biology
REACT_116125Disease
REACT_115662Downregulation of ERBB2:ERBB3 signaling
REACT_118638Downstream signaling events of B Cell Receptor (BCR)
REACT_21272Downstream signaling of activated FGFR
REACT_17025Downstream signal transduction
REACT_163936Fc epsilon receptor (FCERI) signaling
REACT_12578GAB1 signalosome
REACT_115854GRB2 events in ERBB2 signaling
REACT_115896GRB7 events in ERBB2 signaling
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_12464PI3K/AKT activation
REACT_147723PI3K/AKT Signaling in Cancer
REACT_21270PI-3K cascade
REACT_116008PI3K events in ERBB2 signaling
REACT_115961PI3K events in ERBB4 signaling
REACT_75829PIP3 activates AKT signaling
REACT_115720PLCG1 events in ERBB2 signaling
REACT_163769Role of LAT2/NTAL/LAB on calcium mobilization
REACT_19277Sema4D induced cell migration and growth-cone collapse
REACT_19259Sema4D in semaphorin signaling
REACT_19271Semaphorin interactions
REACT_115993SHC1 events in ERBB2 signaling
REACT_9417Signaling by EGFR
REACT_115871Signaling by EGFR in Cancer
REACT_268269Signaling by EGFRvIII in Cancer
REACT_115755Signaling by ERBB2
REACT_115596Signaling by ERBB4
REACT_9470Signaling by FGFR
REACT_120736Signaling by FGFR in disease
REACT_268006Signaling by Ligand-Responsive EGFR Variants in Cancer
REACT_268546Signaling by Overexpressed Wild-Type EGFR in Cancer
REACT_16888Signaling by PDGF
REACT_111040Signaling by SCF-KIT
REACT_118773Signaling by the B Cell Receptor (BCR)
REACT_11061Signalling by NGF
REACT_111102Signal Transduction
SMP Pathway Links
SMP IDDescription
SMP00582Joubert syndrome
SMP00463Phosphatidylinositol Phosphate Metabolism
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