MGP Database

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MGP000987

Ontology/Pathway Information

Entrez Gene ID2081
Gene Nameendoplasmic reticulum to nucleus signaling 1
Gene Symbol ERN1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005737 IDA:UniProtKBCcytoplasm
GO:0005783 IDA:UniProtKBCendoplasmic reticulum
GO:0005789 TAS:ReactomeCendoplasmic reticulum membrane
GO:0030176 IDA:UniProtKBCintegral component of endoplasmic reticulum membrane
GO:0005739 IEA:EnsemblCmitochondrion
GO:0005637 IEA:EnsemblCnuclear inner membrane
GO:0043531 IDA:ParkinsonsUK-UCLFADP binding
GO:0005524 IDA:UniProtKBFATP binding
GO:0004521 IDA:UniProtKBFendoribonuclease activity
GO:0019899 IPI:UniProtKBFenzyme binding
GO:0042802 IPI:IntActFidentical protein binding
GO:0000287 IDA:UniProtKBFmagnesium ion binding
GO:0042803 IDA:ParkinsonsUK-UCLFprotein homodimerization activity
GO:0004674 IDA:UniProtKBFprotein serine/threonine kinase activity
GO:0006987 IDA:UniProtKBPactivation of signaling protein activity involved in unfolded protein response
GO:0007050 ISS:UniProtKBPcell cycle arrest
GO:0044267 TAS:ReactomePcellular protein metabolic process
GO:0035924 IDA:UniProtKBPcellular response to vascular endothelial growth factor stimulus
GO:0030968 TAS:ReactomePendoplasmic reticulum unfolded protein response
GO:0001935 IDA:UniProtKBPendothelial cell proliferation
GO:0070055 IDA:WormBasePHAC1-type intron splice site recognition and cleavage
GO:0070059 IEA:EnsemblPintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0006379 IDA:ParkinsonsUK-UCLPmRNA cleavage
GO:0070054 IDA:UniProtKBPmRNA splicing, via endonucleolytic cleavage and ligation
GO:0036289 IDA:ParkinsonsUK-UCLPpeptidyl-serine autophosphorylation
GO:1900103 IMP:UniProtKBPpositive regulation of endoplasmic reticulum unfolded protein response
GO:0033120 IDA:UniProtKBPpositive regulation of RNA splicing
GO:0006468 IDA:UniProtKBPprotein phosphorylation
GO:0036290 IMP:ParkinsonsUK-UCLPprotein trans-autophosphorylation
GO:0006355 IEA:UniProtKB-KWPregulation of transcription, DNA-templated
GO:0090502 IDA:GOCPRNA phosphodiester bond hydrolysis, endonucleolytic
GO:0008380 IMP:ParkinsonsUK-UCLPRNA splicing
GO:0006351 IEA:UniProtKB-KWPtranscription, DNA-templated
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_18368IRE1alpha activates chaperones
REACT_17015Metabolism of proteins
REACT_18356Unfolded Protein Response (UPR)
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