MGP Database

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MGP000988

Ontology/Pathway Information

Entrez Gene ID2099
Gene Nameestrogen receptor 1
Gene Symbol ESR1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005737 IDA:UniProtKBCcytoplasm
GO:0005794 IEA:UniProtKB-SubCellCGolgi apparatus
GO:0016021 IEA:UniProtKB-KWCintegral component of membrane
GO:0016020 NAS:UniProtKBCmembrane
GO:0005654 TAS:ReactomeCnucleoplasm
GO:0005634 IDA:UniProtKBCnucleus
GO:0005886 IDA:UniProtKBCplasma membrane
GO:0035327 IDA:UniProtKBCtranscriptionally active chromatin
GO:0008013 IPI:BHF-UCLFbeta-catenin binding
GO:0003682 IDA:UniProtKBFchromatin binding
GO:0001046 IDA:UniProtKBFcore promoter sequence-specific DNA binding
GO:0019899 IPI:UniProtKBFenzyme binding
GO:0038052 IGI:MGIFestrogen-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0030284 NAS:UniProtKBFestrogen receptor activity
GO:0034056 IDA:UniProtKBFestrogen response element binding
GO:0042802 IPI:IntActFidentical protein binding
GO:0030235 NAS:UniProtKBFnitric-oxide synthase regulator activity
GO:0000978 IDA:NTNU_SBFRNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077 IDA:NTNU_SBFRNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003700 NAS:BHF-UCLFsequence-specific DNA binding transcription factor activity
GO:0005496 ISS:UniProtKBFsteroid binding
GO:0003707 TAS:ProtIncFsteroid hormone receptor activity
GO:0008134 IPI:UniProtKBFtranscription factor binding
GO:0008270 IEA:InterProFzinc ion binding
GO:0008209 IEA:EnsemblPandrogen metabolic process
GO:0001547 IEA:EnsemblPantral ovarian follicle growth
GO:0071392 ISS:UniProtKBPcellular response to estradiol stimulus
GO:0006338 NAS:UniProtKBPchromatin remodeling
GO:0002064 IEA:EnsemblPepithelial cell development
GO:0060750 IEA:EnsemblPepithelial cell proliferation involved in mammary gland duct elongation
GO:0010467 TAS:ReactomePgene expression
GO:0030520 NAS:UniProtKBPintracellular estrogen receptor signaling pathway
GO:0030518 ISS:UniProtKBPintracellular steroid hormone receptor signaling pathway
GO:0008584 IEA:EnsemblPmale gonad development
GO:0060749 IEA:EnsemblPmammary gland alveolus development
GO:0060745 IEA:EnsemblPmammary gland branching involved in pregnancy
GO:0010629 IDA:UniProtKBPnegative regulation of gene expression
GO:0043124 IDA:UniProtKBPnegative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043433 IDA:UniProtKBPnegative regulation of sequence-specific DNA binding transcription factor activity
GO:0007200 ISS:UniProtKBPphospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007204 ISS:UniProtKBPpositive regulation of cytosolic calcium ion concentration
GO:0048146 IEA:EnsemblPpositive regulation of fibroblast proliferation
GO:0045429 IDA:UniProtKBPpositive regulation of nitric oxide biosynthetic process
GO:0051000 IDA:UniProtKBPpositive regulation of nitric-oxide synthase activity
GO:0010863 ISS:UniProtKBPpositive regulation of phospholipase C activity
GO:0048386 IDA:BHF-UCLPpositive regulation of retinoic acid receptor signaling pathway
GO:0051091 IDA:UniProtKBPpositive regulation of sequence-specific DNA binding transcription factor activity
GO:0045944 IDA:UniProtKBPpositive regulation of transcription from RNA polymerase II promoter
GO:0060527 IEA:EnsemblPprostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
GO:0060523 IEA:EnsemblPprostate epithelial cord elongation
GO:0042981 IEA:EnsemblPregulation of apoptotic process
GO:0060687 IEA:EnsemblPregulation of branching involved in prostate gland morphogenesis
GO:0006355 NAS:UniProtKBPregulation of transcription, DNA-templated
GO:0032355 IDA:BHF-UCLPresponse to estradiol
GO:0043627 IDA:UniProtKBPresponse to estrogen
GO:0007165 TAS:ProtIncPsignal transduction
GO:0006351 TAS:ProtIncPtranscription, DNA-templated
GO:0006367 TAS:ReactomePtranscription initiation from RNA polymerase II promoter
GO:0060065 IEA:EnsemblPuterus development
GO:0060068 IEA:EnsemblPvagina development
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_71Gene Expression
REACT_12627Generic Transcription Pathway
REACT_15525Nuclear Receptor transcription pathway
REACT_116022Nuclear signaling by ERBB4
REACT_115596Signaling by ERBB4
REACT_111102Signal Transduction
SMP Pathway Links
SMP IDDescription
SMP00309Excitatory Neural Signalling Through 5-HTR 4 and Serotonin
SMP00312Excitatory Neural Signalling Through 5-HTR 6 and Serotonin
SMP00311Excitatory Neural Signalling Through 5-HTR 7 and Serotonin
SMP00333Intracellular Signalling Through FSH Receptor and Follicle Stimulating Hormone
SMP00335Intracellular Signalling Through Histamine H2 Receptor and Histamine
SMP00338Intracellular Signalling Through LHCGR Receptor and Luteinizing Hormone/Choriogonadotropin
SMP00471Tamoxifen Action Pathway
SMP00606Tamoxifen Metabolism Pathway
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