MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP000997

UniProt Annotations

Entry Information
Gene Namev-ets avian erythroblastosis virus E26 oncogene homolog 1
Protein EntryETS1_HUMAN
UniProt IDP14921
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=5; Name=c-ETS-1A; Synonyms=Ets-1 p51; IsoId=P14921-1; Sequence=Displayed; Name=c-ETS-1B; Synonyms=Ets-1 p42; IsoId=P14921-2; Sequence=VSP_001464; Name=3; IsoId=P14921-3; Sequence=VSP_043152; Note=No experimental confirmation available.; Name=Ets-1 p27; Synonyms=Ets-1Delta(III-VI); IsoId=P14921-4; Sequence=VSP_046056; Note=Acts as a dominant-negative for isoform c-ETS-1A.; Name=5; IsoId=P14921-5; Sequence=VSP_055485, VSP_055486; Note=No experimental confirmation available.;
FunctionTranscription factor. Directly controls the expression of cytokine and chemokine genes in a wide variety of different cellular contexts. May control the differentiation, survival and proliferation of lymphoid cells. May also regulate angiogenesis through regulation of expression of genes controlling endothelial cell migration and invasion. {ECO:0000269|PubMed:10698492, ECO:0000269|PubMed:11909962, ECO:0000269|PubMed:15247905, ECO:0000269|PubMed:15592518}.
InductionUp-regulated by retinoic acid, VEGF, TNF-alpha/TNFA, lipopolysaccharide and in response to hypoxia (at protein level). {ECO:0000269|PubMed:15592518}.
InteractionQ06481:APLP2; NbExp=2; IntAct=EBI-913209, EBI-79306; Q4LE39:ARID4B; NbExp=2; IntAct=EBI-913209, EBI-2680990; Q9BQA9:C17orf62; NbExp=3; IntAct=EBI-913209, EBI-2680384; Q9UER7-1:DAXX; NbExp=3; IntAct=EBI-913224, EBI-287635; O60841:EIF5B; NbExp=2; IntAct=EBI-913209, EBI-928530; P70338:Gfi1 (xeno); NbExp=2; IntAct=EBI-913209, EBI-3954754; P05412:JUN; NbExp=3; IntAct=EBI-913209, EBI-852823; P28482:MAPK1; NbExp=3; IntAct=EBI-913209, EBI-959949; O00470:MEIS1; NbExp=2; IntAct=EBI-913209, EBI-1210694; P78527:PRKDC; NbExp=2; IntAct=EBI-913209, EBI-352053; Q8NHY2:RFWD2; NbExp=3; IntAct=EBI-913224, EBI-1176214; P23497:SP100; NbExp=4; IntAct=EBI-913209, EBI-751145; P12931:SRC; NbExp=2; IntAct=EBI-913224, EBI-621482; Q05519:SRSF11; NbExp=2; IntAct=EBI-913209, EBI-1051785; P17542:TAL1; NbExp=2; IntAct=EBI-913209, EBI-1753878;
PtmSumoylated on Lys-15 and Lys-227, preferentially with SUMO2; which inhibits transcriptional activity. {ECO:0000250}.
PtmUbiquitinated; which induces proteasomal degradation. {ECO:0000250}.
SimilarityBelongs to the ETS family. {ECO:0000305}.
SimilarityContains 1 ETS DNA-binding domain. {ECO:0000255|PROSITE-ProRule:PRU00237}.
SimilarityContains 1 PNT (pointed) domain. {ECO:0000255|PROSITE- ProRule:PRU00762}.
Subcellular LocationCytoplasm. Nucleus. Note=Delocalizes from nucleus to cytoplasm when coexpressed with isoform Ets-1 p27.
SubunitBinds DNA as a homodimer; homodimerization is required for transcription activation. Interacts with MAF and MAFB. Interacts with PAX5; the interaction alters DNA-binding properties (By similarity). Interacts with DAXX. Interacts with UBE2I. Interacts with SP100; the interaction is direct and modulates ETS1 transcriptional activity. {ECO:0000250, ECO:0000269|PubMed:11909962, ECO:0000269|PubMed:15247905, ECO:0000269|PubMed:18566588, ECO:0000269|PubMed:9333025}.
Tissue SpecificityHighly expressed within lymphoid cells. Isoforms c-ETS-1A and Ets-1 p27 are both detected in all fetal tissues tested, but vary with tissue type in adult tissues. None is detected in brain or kidney. {ECO:0000269|PubMed:19377509, ECO:0000269|PubMed:20378371}.
Web ResourceName=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/ETS1ID40502ch11q24.html";
  logo