MGP Database

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MGP000998

UniProt Annotations

Entry Information
Gene Namev-ets avian erythroblastosis virus E26 oncogene homolog 2
Protein Entry
UniProt ID
SpeciesHuman
Comments
Comment typeDescription
FunctionTranscription factor activating transcription. Binds specifically the DNA GGAA/T core motif (Ets-binding site or EBS) in gene promoters and stimulates transcription. {ECO:0000269|PubMed:11909962}.
InteractionQ15131:CDK10; NbExp=2; IntAct=EBI-1646991, EBI-1646959; Q15672:TWIST1; NbExp=2; IntAct=EBI-1646991, EBI-1797287; Q8WVJ9:TWIST2; NbExp=2; IntAct=EBI-1646991, EBI-1797313;
PtmPhosphorylation by CDK10 at Ser-220 and Ser-225 creates a phosphodegron that targets ETS2 for proteasomal degradation. {ECO:0000269|PubMed:18691976, ECO:0000269|PubMed:24218572}.
SimilarityBelongs to the ETS family. {ECO:0000305}.
SimilarityContains 1 ETS DNA-binding domain. {ECO:0000255|PROSITE-ProRule:PRU00237}.
SimilarityContains 1 PNT (pointed) domain. {ECO:0000255|PROSITE- ProRule:PRU00762}.
Subcellular LocationNucleus.
Web ResourceName=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/ETS2ID40503ch21q22.html";
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