MGP Database

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MGP001004

Ontology/Pathway Information

Entrez Gene ID2147
Gene Namecoagulation factor II (thrombin)
Gene Symbol F2
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0072562 IDA:UniProtKBCblood microparticle
GO:0005788 TAS:ReactomeCendoplasmic reticulum lumen
GO:0005576 TAS:ReactomeCextracellular region
GO:0005615 IDA:UniProtKBCextracellular space
GO:0070062 IDA:UniProtKBCextracellular vesicular exosome
GO:0005796 TAS:ReactomeCGolgi lumen
GO:0005886 TAS:ReactomeCplasma membrane
GO:0005509 IEA:InterProFcalcium ion binding
GO:0008083 TAS:BHF-UCLFgrowth factor activity
GO:0005102 IPI:UniProtKBFreceptor binding
GO:0004252 IDA:UniProtKBFserine-type endopeptidase activity
GO:0070053 IDA:BHF-UCLFthrombospondin receptor activity
GO:0006953 IEA:UniProtKB-KWPacute-phase response
GO:0007596 TAS:ReactomePblood coagulation
GO:0007597 TAS:ReactomePblood coagulation, intrinsic pathway
GO:0007166 IDA:BHF-UCLPcell surface receptor signaling pathway
GO:0044267 TAS:ReactomePcellular protein metabolic process
GO:0051480 IDA:BHF-UCLPcytosolic calcium ion homeostasis
GO:0042730 IDA:UniProtKBPfibrinolysis
GO:0050900 TAS:ReactomePleukocyte migration
GO:0007275 TAS:ProtIncPmulticellular organismal development
GO:0048712 IDA:BHF-UCLPnegative regulation of astrocyte differentiation
GO:0051918 TAS:BHF-UCLPnegative regulation of fibrinolysis
GO:0010544 TAS:BHF-UCLPnegative regulation of platelet activation
GO:0045861 IDA:BHF-UCLPnegative regulation of proteolysis
GO:0017187 TAS:ReactomePpeptidyl-glutamic acid carboxylation
GO:0030168 IDA:BHF-UCLPplatelet activation
GO:0030194 IDA:BHF-UCLPpositive regulation of blood coagulation
GO:0030307 IEA:EnsemblPpositive regulation of cell growth
GO:0008284 IEA:EnsemblPpositive regulation of cell proliferation
GO:0032967 IDA:BHF-UCLPpositive regulation of collagen biosynthetic process
GO:0014068 IEA:EnsemblPpositive regulation of phosphatidylinositol 3-kinase signaling
GO:1900738 IDA:BHF-UCLPpositive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0001934 IDA:BHF-UCLPpositive regulation of protein phosphorylation
GO:2000379 IDA:UniProtKBPpositive regulation of reactive oxygen species metabolic process
GO:0051281 IDA:BHF-UCLPpositive regulation of release of sequestered calcium ion into cytosol
GO:0043687 TAS:ReactomePpost-translational protein modification
GO:0006508 TAS:ReactomePproteolysis
GO:0030193 TAS:UniProtKBPregulation of blood coagulation
GO:0008360 IEA:EnsemblPregulation of cell shape
GO:0009611 IDA:BHF-UCLPresponse to wounding
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_12051Cell surface interactions at the vascular wall
REACT_14828Class A/1 (Rhodopsin-like receptors)
REACT_1439Common Pathway
REACT_267874Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
REACT_116125Disease
REACT_2051Formation of Fibrin Clot (Clotting Cascade)
REACT_18283G alpha (q) signalling events
REACT_1069Gamma carboxylation, hypusine formation and arylsulfatase activation
REACT_1050Gamma-carboxylation of protein precursors
REACT_1132Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
REACT_120966Gastrin-CREB signalling pathway via PKC and MAPK
REACT_19184GPCR downstream signaling
REACT_21340GPCR ligand binding
REACT_604Hemostasis
REACT_326Intrinsic Pathway
REACT_267615Metabolic disorders of biological oxidation enzymes
REACT_17015Metabolism of proteins
REACT_14819Peptide ligand-binding receptors
REACT_798Platelet activation, signaling and aggregation
REACT_278Platelet Aggregation (Plug Formation)
REACT_22161Post-translational protein modification
REACT_15428Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
REACT_733Removal of aminoterminal propeptides from gamma-carboxylated proteins
REACT_14797Signaling by GPCR
REACT_111102Signal Transduction
REACT_21384Thrombin signalling through proteinase activated receptors (PARs)
REACT_1906Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
SMP Pathway Links
SMP IDDescription
SMP00269Acenocoumarol Action Pathway
SMP00280Alteplase Action Pathway
SMP00286Aminocaproic Acid Action Pathway
SMP00281Anistreplase Action Pathway
SMP00288Aprotinin Action Pathway
SMP00275Ardeparin Action Pathway
SMP00276Argatroban Action Pathway
SMP00277Bivalirudin Action Pathway
SMP00586Coagulation
SMP00656Dicoumarol Action Pathway
SMP00270Dicumarol Action Pathway
SMP00272Enoxaparin Action Pathway
SMP00273Fondaparinux Action Pathway
SMP00274Heparin Action Pathway
SMP00278Lepirudin Action Pathway
SMP00655Phenindione Action Pathway
SMP00271Phenprocoumon Action Pathway
SMP00285Reteplase Action Pathway
SMP00282Streptokinase Action Pathway
SMP00283Tenecteplase Action Pathway
SMP00287Tranexamic Acid Action Pathway
SMP00284Urokinase Action Pathway
SMP00464Vitamin K Metabolism
SMP00268Warfarin Action Pathway
SMP00279Ximelagatran Action Pathway
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