MGP Database

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MGP001011

Ontology/Pathway Information

Entrez Gene ID2157
Gene Namecoagulation factor VIII, procoagulant component
Gene Symbol F8
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005576 NAS:UniProtKBCextracellular region
GO:0005615 IEA:UniProtKB-SubCellCextracellular space
GO:0005886 TAS:ReactomeCplasma membrane
GO:0031093 TAS:ReactomeCplatelet alpha granule lumen
GO:0005507 IEA:InterProFcopper ion binding
GO:0016491 IEA:InterProFoxidoreductase activity
GO:0004252 IEA:EnsemblFserine-type endopeptidase activity
GO:0006953 IEA:UniProtKB-KWPacute-phase response
GO:0007596 TAS:ReactomePblood coagulation
GO:0007597 TAS:ReactomePblood coagulation, intrinsic pathway
GO:0007155 IEA:InterProPcell adhesion
GO:0030168 TAS:ReactomePplatelet activation
GO:0002576 TAS:ReactomePplatelet degranulation
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_1439Common Pathway
REACT_2051Formation of Fibrin Clot (Clotting Cascade)
REACT_604Hemostasis
REACT_326Intrinsic Pathway
REACT_798Platelet activation, signaling and aggregation
REACT_318Platelet degranulation
REACT_1280Response to elevated platelet cytosolic Ca2+
SMP Pathway Links
SMP IDDescription
SMP00269Acenocoumarol Action Pathway
SMP00280Alteplase Action Pathway
SMP00286Aminocaproic Acid Action Pathway
SMP00281Anistreplase Action Pathway
SMP00288Aprotinin Action Pathway
SMP00275Ardeparin Action Pathway
SMP00276Argatroban Action Pathway
SMP00277Bivalirudin Action Pathway
SMP00586Coagulation
SMP00656Dicoumarol Action Pathway
SMP00270Dicumarol Action Pathway
SMP00272Enoxaparin Action Pathway
SMP00273Fondaparinux Action Pathway
SMP00274Heparin Action Pathway
SMP00278Lepirudin Action Pathway
SMP00655Phenindione Action Pathway
SMP00271Phenprocoumon Action Pathway
SMP00285Reteplase Action Pathway
SMP00282Streptokinase Action Pathway
SMP00283Tenecteplase Action Pathway
SMP00287Tranexamic Acid Action Pathway
SMP00284Urokinase Action Pathway
SMP00268Warfarin Action Pathway
SMP00279Ximelagatran Action Pathway
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