MGP Database

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MGP001018

UniProt Annotations

Entry Information
Gene Namefatty acid binding protein 4, adipocyte
Protein EntryFABP4_HUMAN
UniProt IDP15090
SpeciesHuman
Comments
Comment typeDescription
DomainForms a beta-barrel structure that accommodates hydrophobic ligands in its interior.
FunctionLipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus (By similarity). {ECO:0000250}.
SimilarityBelongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. {ECO:0000305}.
Subcellular LocationCytoplasm. Nucleus. Note=Depending on the nature of the ligand, a conformation change exposes a nuclear localization motif and the protein is transported into the nucleus. Subject to constitutive nuclear export (By similarity). {ECO:0000250}.
SubunitHomodimer. Interacts with PPARG (By similarity). Monomer. {ECO:0000250, ECO:0000269|PubMed:15357969, ECO:0000269|PubMed:17077479}.
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