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MGP001027

Record overview

MGPD IDMGP001027
Gene ID2181
SpeciesHomo sapiens (Human)
Gene Nameacyl-CoA synthetase long-chain family member 3
Gene Symbol ACSL3
SynonymsACS3; FACL3; PRO2194;
Alternate nameslong-chain-fatty-acid--CoA ligase 3; LACS 3; fatty-acid-Coenzyme A ligase, long-chain 3; lignoceroyl-CoA synthase; long-chain acyl-CoA synthetase 3;
Chromosome2
Map Location2q34-q35
EC Number6.2.1.3
SummaryThe protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in brain, and preferentially utilizes myristate, arachidonate, and eicosapentaenoate as substrates. The amino acid sequence of this isozyme is 92% identical to that of rat homolog. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for ACSL3

Proteins

long-chain-fatty-acid--CoA ligase 3
Refseq ID:NP_004448
Protein GI:42794752
UniProt ID:O95573
mRNA ID:NM_004457
Length:720
RefSeq Status:
MNNHVSSKPSTMKLKHTINPILLYFIHFLISLYTILTYIPFYFFSESRQEKSNRIKAKPVNSKPDSAYRSVNSLDGLASVLYPGCDTLDKVFTYAKNKFK
NKRLLGTREVLNEEDEVQPNGKIFKKVILGQYNWLSYEDVFVRAFNFGNGLQMLGQKPKTNIAIFCETRAEWMIAAQACFMYNFQLVTLYATLGGPAIVH
ALNETEVTNIITSKELLQTKLKDIVSLVPRLRHIITVDGKPPTWSEFPKGIIVHTMAAVEALGAKASMENQPHSKPLPSDIAVIMYTSGSTGLPKGVMIS
HSNIIAGITGMAERIPELGEEDVYIGYLPLAHVLELSAELVCLSHGCRIGYSSPQTLADQSSKIKKGSKGDTSMLKPTLMAAVPEIMDRIYKNVMNKVSE
MSSFQRNLFILAYNYKMEQISKGRNTPLCDSFVFRKVRSLLGGNIRLLLCGGAPLSATTQRFMNICFCCPVGQGYGLTESAGAGTISEVWDYNTGRVGAP
LVCCEIKLKNWEEGGYFNTDKPHPRGEILIGGQSVTMGYYKNEAKTKADFFEDENGQRWLCTGDIGEFEPDGCLKIIDRKKDLVKLQAGEYVSLGKVEAA
LKNLPLVDNICAYANSYHSYVIGFVVPNQKELTELARKKGLKGTWEELCNSCEMENEVLKVLSEAAISASLEKFEIPVKIRLSPEPWTPETGLVTDAFKL
KRKELKTHYQADIERMYGRK
 
long-chain-fatty-acid--CoA ligase 3
Refseq ID:NP_976251
Protein GI:42794754
UniProt ID:O95573
mRNA ID:NM_203372
Length:720
RefSeq Status:
Protein sequence is identical to GI:42794752 (mRNA isoform)
 
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