MGP Database

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MGP001030

Ontology/Pathway Information

Entrez Gene ID2185
Gene Nameprotein tyrosine kinase 2 beta
Gene Symbol PTK2B
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0097440 ISS:Alzheimers_University_of_TorontoCapical dendrite
GO:0030424 IEA:EnsemblCaxon
GO:0044297 ISS:Alzheimers_University_of_TorontoCcell body
GO:0005938 IEA:UniProtKB-SubCellCcell cortex
GO:0005737 IDA:HPACcytoplasm
GO:0005856 IEA:InterProCcytoskeleton
GO:0005829 TAS:ReactomeCcytosol
GO:0030425 ISS:Alzheimers_University_of_TorontoCdendrite
GO:0031234 IBA:GO_CentralCextrinsic component of cytoplasmic side of plasma membrane
GO:0005925 IDA:UniProtKBCfocal adhesion
GO:0030426 ISS:Alzheimers_University_of_TorontoCgrowth cone
GO:0030027 IDA:UniProtKBClamellipodium
GO:0045121 IEA:EnsemblCmembrane raft
GO:0043025 ISS:Alzheimers_University_of_TorontoCneuronal cell body
GO:0017146 ISS:Alzheimers_University_of_TorontoCN-methyl-D-aspartate selective glutamate receptor complex
GO:0005654 IDA:HPACnucleoplasm
GO:0005634 IDA:UniProtKBCnucleus
GO:0048471 IDA:UniProtKBCperinuclear region of cytoplasm
GO:0014069 ISS:Alzheimers_University_of_TorontoCpostsynaptic density
GO:0005524 IEA:UniProtKB-KWFATP binding
GO:0004683 ISS:Alzheimers_University_of_TorontoFcalmodulin-dependent protein kinase activity
GO:0004972 IEA:EnsemblFN-methyl-D-aspartate selective glutamate receptor activity
GO:0004715 IDA:UniProtKBFnon-membrane spanning protein tyrosine kinase activity
GO:0004713 TAS:ProtIncFprotein tyrosine kinase activity
GO:0005102 IBA:GO_CentralFreceptor binding
GO:0004871 NAS:ProtIncFsignal transducer activity
GO:0042976 IMP:UniProtKBPactivation of Janus kinase activity
GO:0032863 IEA:EnsemblPactivation of Rac GTPase activity
GO:0001525 IBA:GO_CentralPangiogenesis
GO:0006915 TAS:ProtIncPapoptotic process
GO:0043534 IEA:EnsemblPblood vessel endothelial cell migration
GO:0045453 ISS:UniProtKBPbone resorption
GO:0007166 IMP:UniProtKBPcell surface receptor signaling pathway
GO:0006968 ISS:Alzheimers_University_of_TorontoPcellular defense response
GO:0071300 IMP:BHF-UCLPcellular response to retinoic acid
GO:0070098 ISS:UniProtKBPchemokine-mediated signaling pathway
GO:0007173 IBA:GO_CentralPepidermal growth factor receptor signaling pathway
GO:0048041 IEA:EnsemblPfocal adhesion assembly
GO:0014009 IEA:EnsemblPglial cell proliferation
GO:0045087 IBA:GO_CentralPinnate immune response
GO:0007229 IMP:UniProtKBPintegrin-mediated signaling pathway
GO:0035235 ISS:Alzheimers_University_of_TorontoPionotropic glutamate receptor signaling pathway
GO:0060291 ISS:Alzheimers_University_of_TorontoPlong-term synaptic potentiation
GO:0000165 IEA:EnsemblPMAPK cascade
GO:0002315 ISS:UniProtKBPmarginal zone B cell differentiation
GO:0043066 IMP:UniProtKBPnegative regulation of apoptotic process
GO:0030502 ISS:UniProtKBPnegative regulation of bone mineralization
GO:0008285 IMP:UniProtKBPnegative regulation of cell proliferation
GO:0010656 IEA:EnsemblPnegative regulation of muscle cell apoptotic process
GO:0045638 IMP:UniProtKBPnegative regulation of myeloid cell differentiation
GO:0043524 ISS:Alzheimers_University_of_TorontoPnegative regulation of neuron apoptotic process
GO:0043267 IDA:UniProtKBPnegative regulation of potassium ion transport
GO:0031175 IEA:EnsemblPneuron projection development
GO:0001556 IEA:EnsemblPoocyte maturation
GO:0038083 ISS:Alzheimers_University_of_TorontoPpeptidyl-tyrosine autophosphorylation
GO:0018108 IDA:UniProtKBPpeptidyl-tyrosine phosphorylation
GO:0030838 IMP:UniProtKBPpositive regulation of actin filament polymerization
GO:2000538 ISS:UniProtKBPpositive regulation of B cell chemotaxis
GO:0030307 IEA:EnsemblPpositive regulation of cell growth
GO:0001954 IMP:UniProtKBPpositive regulation of cell-matrix adhesion
GO:0030335 IMP:UniProtKBPpositive regulation of cell migration
GO:0008284 IMP:UniProtKBPpositive regulation of cell proliferation
GO:0007204 IEA:EnsemblPpositive regulation of cytosolic calcium ion concentration
GO:0010595 IDA:BHF-UCLPpositive regulation of endothelial cell migration
GO:0070374 IMP:UniProtKBPpositive regulation of ERK1 and ERK2 cascade
GO:2000463 ISS:Alzheimers_University_of_TorontoPpositive regulation of excitatory postsynaptic membrane potential
GO:0046330 IMP:UniProtKBPpositive regulation of JNK cascade
GO:0043507 IEA:EnsemblPpositive regulation of JUN kinase activity
GO:0010976 IMP:BHF-UCLPpositive regulation of neuron projection development
GO:0050731 IDA:BHF-UCLPpositive regulation of peptidyl-tyrosine phosphorylation
GO:0043552 ISS:UniProtKBPpositive regulation of phosphatidylinositol 3-kinase activity
GO:0045860 IMP:UniProtKBPpositive regulation of protein kinase activity
GO:2000379 IEA:EnsemblPpositive regulation of reactive oxygen species metabolic process
GO:0051968 ISS:Alzheimers_University_of_TorontoPpositive regulation of synaptic transmission, glutamatergic
GO:0045727 IEA:EnsemblPpositive regulation of translation
GO:0046777 TAS:UniProtKBPprotein autophosphorylation
GO:0006461 TAS:ProtIncPprotein complex assembly
GO:0006468 TAS:ProtIncPprotein phosphorylation
GO:2000249 ISS:UniProtKBPregulation of actin cytoskeleton reorganization
GO:0030155 IMP:UniProtKBPregulation of cell adhesion
GO:0008360 IMP:UniProtKBPregulation of cell shape
GO:2000114 ISS:UniProtKBPregulation of establishment of cell polarity
GO:0032960 ISS:UniProtKBPregulation of inositol trisphosphate biosynthetic process
GO:0010758 ISS:UniProtKBPregulation of macrophage chemotaxis
GO:2000310 ISS:Alzheimers_University_of_TorontoPregulation of N-methyl-D-aspartate selective glutamate receptor activity
GO:2000058 IDA:UniProtKBPregulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0051279 ISS:UniProtKBPregulation of release of sequestered calcium ion into cytosol
GO:0051592 IEA:EnsemblPresponse to calcium ion
GO:0051591 IEA:EnsemblPresponse to cAMP
GO:0042220 IEA:EnsemblPresponse to cocaine
GO:0042493 IEA:EnsemblPresponse to drug
GO:0045471 IEA:EnsemblPresponse to ethanol
GO:0009749 IEA:EnsemblPresponse to glucose
GO:0009725 IEA:EnsemblPresponse to hormone
GO:0042542 IEA:EnsemblPresponse to hydrogen peroxide
GO:0001666 IEA:EnsemblPresponse to hypoxia
GO:0035902 IEA:EnsemblPresponse to immobilization stress
GO:0010226 IEA:EnsemblPresponse to lithium ion
GO:0009612 IEA:EnsemblPresponse to mechanical stimulus
GO:0006970 IEA:EnsemblPresponse to osmotic stress
GO:0006950 TAS:ProtIncPresponse to stress
GO:0007172 TAS:ProtIncPsignal complex assembly
GO:0007165 TAS:ProtIncPsignal transduction
GO:0002040 ISS:UniProtKBPsprouting angiogenesis
GO:0043149 IEA:EnsemblPstress fiber assembly
GO:0033209 IMP:UniProtKBPtumor necrosis factor-mediated signaling pathway
GO:0048010 IMP:BHF-UCLPvascular endothelial growth factor receptor signaling pathway
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_111155Cell-Cell communication
REACT_75790Cytokine Signaling in Immune system
REACT_6900Immune System
REACT_27283Interleukin-2 signaling
REACT_22232Signaling by Interleukins
REACT_12529Signaling by VEGF
REACT_23916Signal regulatory protein (SIRP) family interactions
REACT_111102Signal Transduction
REACT_264464VEGFA-VEGFR2 Pathway
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