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MGP001052

UniProt Annotations

Entry Information
Gene Nameficolin (collagen/fibrinogen domain containing lectin) 2
Protein EntryFCN2_HUMAN
UniProt IDQ15485
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q15485-1; Sequence=Displayed; Name=2; IsoId=Q15485-2; Sequence=VSP_030027; Note=No experimental confirmation available.;
DomainThe fibrinogen-like domain (FBG) contains potential calcium-binding sites that may be involved in carbohydrate binding.
FunctionMay function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc- binding lectin. Enhances phagocytosis of S.typhimurium by neutrophils, suggesting an opsonic effect via the collagen region. {ECO:0000269|PubMed:10679061}.
InteractionQ07954:LRP1; NbExp=2; IntAct=EBI-7468784, EBI-1046087;
SimilarityBelongs to the ficolin lectin family. {ECO:0000305}.
SimilarityContains 1 collagen-like domain. {ECO:0000305}.
SimilarityContains 1 fibrinogen C-terminal domain. {ECO:0000255|PROSITE-ProRule:PRU00739}.
Subcellular LocationSecreted.
SubunitHomopolymer; disulfide-linked. Interacts with elastin. Interacts with MASP1 and MASP2. {ECO:0000269|PubMed:10679061, ECO:0000269|PubMed:8586615}.
Tissue SpecificityExpressed by the liver and secreted in plasma.
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