MGP Database

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MGP001055

UniProt Annotations

Entry Information
Gene Nameferredoxin 1
Protein EntryADX_HUMAN
UniProt IDP10109
SpeciesHuman
Comments
Comment typeDescription
Biophysicochemical PropertiesRedox potential: E(0) is -448 mV.;
CofactorName=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:49601; Evidence={ECO:0000269|PubMed:21636783, ECO:0000269|Ref.13}; Note=Binds 1 [2Fe-2S] cluster. {ECO:0000269|PubMed:21636783, ECO:0000269|Ref.13};
FunctionParticipates in the synthesis of thyroid hormones. Essential for the synthesis of various steroid hormones, participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis. Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 that catalyzes cholesterol side-chain cleavage. {ECO:0000269|PubMed:20547883, ECO:0000269|PubMed:21636783}.
SimilarityBelongs to the adrenodoxin/putidaredoxin family. {ECO:0000305}.
SimilarityContains 1 2Fe-2S ferredoxin-type domain. {ECO:0000255|PROSITE-ProRule:PRU00465}.
Subcellular LocationMitochondrion matrix {ECO:0000269|PubMed:20547883}.
SubunitInteracts with CYP11A1. {ECO:0000269|PubMed:21636783, ECO:0000269|Ref.13}.
Tissue SpecificityHighest levels in the adrenal gland (at protein level). Also detected in kidney and testis (at protein level). {ECO:0000269|PubMed:20547883}.
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