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MGP001056

UniProt Annotations

Entry Information
Gene Nameferredoxin reductase
Protein Entry
UniProt ID
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=7; Name=Short; IsoId=P22570-1; Sequence=Displayed; Name=Long; IsoId=P22570-2; Sequence=VSP_003416; Note=Represents 10-20% of all adrenodoxin reductase mRNAs and seems to be inactive.; Name=3; IsoId=P22570-3; Sequence=VSP_045135; Name=4; IsoId=P22570-4; Sequence=VSP_046669; Name=5; IsoId=P22570-5; Sequence=VSP_046673; Name=6; IsoId=P22570-6; Sequence=VSP_046671, VSP_046672; Note=No experimental confirmation available.; Name=7; IsoId=P22570-7; Sequence=VSP_046670; Note=No experimental confirmation available.;
Catalytic Activity2 reduced adrenodoxin + NADP(+) = 2 oxidized adrenodoxin + NADPH.
CofactorName=FAD; Xref=ChEBI:CHEBI:57692;
FunctionServes as the first electron transfer protein in all the mitochondrial P450 systems. Including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver.
InteractionP49789:FHIT; NbExp=4; IntAct=EBI-1751533, EBI-741760;
PathwaySteroid metabolism; cholesterol metabolism.
SimilarityBelongs to the ferredoxin--NADP reductase type 1 family. {ECO:0000305}.
Subcellular LocationMitochondrion matrix.
SubunitMonomer. Interacts directly with FDX1. {ECO:0000250|UniProtKB:P08165}.
Web ResourceName=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/fdxr/";
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