MGP Database

MGP001057

Ontology/Pathway Information

Entrez Gene ID	2235
Gene Name	ferrochelatase
Gene Symbol	FECH
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005743	IEA:UniProtKB-SubCell	C	mitochondrial inner membrane
GO:0005759	TAS:Reactome	C	mitochondrial matrix
GO:0051537	IEA:UniProtKB-KW	F	2 iron, 2 sulfur cluster binding
GO:0004325	IDA:BHF-UCL	F	ferrochelatase activity
GO:0008198	TAS:ProtInc	F	ferrous iron binding
GO:0020037	IEA:Ensembl	F	heme binding
GO:0030350	IEA:Ensembl	F	iron-responsive element binding
GO:0071549	IEA:Ensembl	P	cellular response to dexamethasone stimulus
GO:0008203	IEA:Ensembl	P	cholesterol metabolic process
GO:0009589	IEA:Ensembl	P	detection of UV
GO:0030218	IEA:Ensembl	P	erythrocyte differentiation
GO:0006091	TAS:ProtInc	P	generation of precursor metabolites and energy
GO:0006783	TAS:Reactome	P	heme biosynthetic process
GO:0055072	IEA:Ensembl	P	iron ion homeostasis
GO:0006778	TAS:Reactome	P	porphyrin-containing compound metabolic process
GO:0046501	IDA:BHF-UCL	P	protoporphyrinogen IX metabolic process
GO:0010999	IEA:Ensembl	P	regulation of eIF2 alpha phosphorylation by heme
GO:0010468	IEA:Ensembl	P	regulation of gene expression
GO:0046984	IEA:Ensembl	P	regulation of hemoglobin biosynthetic process
GO:0046685	IEA:Ensembl	P	response to arsenic-containing substance
GO:0042493	IEA:Ensembl	P	response to drug
GO:0045471	IEA:Ensembl	P	response to ethanol
GO:0017085	IEA:Ensembl	P	response to insecticide
GO:0010288	IEA:Ensembl	P	response to lead ion
GO:0009416	TAS:ProtInc	P	response to light stimulus
GO:0051597	IEA:Ensembl	P	response to methylmercury
GO:0070541	IEA:Ensembl	P	response to platinum ion
GO:0044281	TAS:Reactome	P	small molecule metabolic process
GO:0034379	IEA:Ensembl	P	very-low-density lipoprotein particle assembly

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_9465	Heme biosynthesis
REACT_111217	Metabolism
REACT_9431	Metabolism of porphyrins

SMP Pathway Links

SMP ID	Description
SMP00344	Acute Intermittent Porphyria
SMP00345	Congenital Erythropoietic Porphyria (CEP) or Gunther Disease
SMP00342	Hereditary Coproporphyria (HCP)
SMP00346	Porphyria Variegata (PV)
SMP00024	Porphyrin Metabolism