MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP001058

Ontology/Pathway Information

Entrez Gene ID2237
Gene Nameflap structure-specific endonuclease 1
Gene Symbol FEN1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0016020 IDA:UniProtKBCmembrane
GO:0005739 IDA:UniProtKBCmitochondrion
GO:0005730 IDA:HPACnucleolus
GO:0005654 TAS:ReactomeCnucleoplasm
GO:0005634 IDA:UniProtKBCnucleus
GO:0005886 IDA:HPACplasma membrane
GO:0008409 IDA:UniProtKBF5'-3' exonuclease activity
GO:0017108 IDA:UniProtKBF5'-flap endonuclease activity
GO:0003684 TAS:ProtIncFdamaged DNA binding
GO:0003677 IMP:UniProtKBFDNA binding
GO:0003690 TAS:ProtIncFdouble-stranded DNA binding
GO:0008309 TAS:ProtIncFdouble-stranded DNA exodeoxyribonuclease activity
GO:0004519 TAS:ProtIncFendonuclease activity
GO:0004527 TAS:ProtIncFexonuclease activity
GO:0000287 IEA:UniProtKB-HAMAPFmagnesium ion binding
GO:0030145 IEA:EnsemblFmanganese ion binding
GO:0004523 IDA:UniProtKBFRNA-DNA hybrid ribonuclease activity
GO:0006284 TAS:ReactomePbase-excision repair
GO:0000737 IDA:GOCPDNA catabolic process, endonucleolytic
GO:0000738 TAS:GOCPDNA catabolic process, exonucleolytic
GO:0006281 TAS:ReactomePDNA repair
GO:0006260 TAS:ProtIncPDNA replication
GO:0043137 IDA:UniProtKBPDNA replication, removal of RNA primer
GO:0006271 TAS:ReactomePDNA strand elongation involved in DNA replication
GO:0006302 TAS:ProtIncPdouble-strand break repair
GO:0007613 IEA:EnsemblPmemory
GO:0000278 TAS:ReactomePmitotic cell cycle
GO:0090502 IDA:GOCPRNA phosphodiester bond hydrolysis, endonucleolytic
GO:0000723 TAS:ReactomePtelomere maintenance
GO:0000722 TAS:ReactomePtelomere maintenance via recombination
GO:0032201 TAS:ReactomePtelomere maintenance via semi-conservative replication
GO:0009650 TAS:ProtIncPUV protection
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_1104Base Excision Repair
REACT_115566Cell Cycle
REACT_152Cell Cycle, Mitotic
REACT_22172Chromosome Maintenance
REACT_216DNA Repair
REACT_383DNA Replication
REACT_932DNA strand elongation
REACT_8030Extension of Telomeres
REACT_312Lagging Strand Synthesis
REACT_8027Processive synthesis on the C-strand of the telomere
REACT_1385Processive synthesis on the lagging strand
REACT_2192Removal of DNA patch containing abasic residue
REACT_70Removal of the Flap Intermediate
REACT_7999Removal of the Flap Intermediate from the C-strand
REACT_1893Resolution of Abasic Sites (AP sites)
REACT_1128Resolution of AP sites via the multiple-nucleotide patch replacement pathway
REACT_899S Phase
REACT_2014Synthesis of DNA
REACT_7961Telomere C-strand (Lagging Strand) Synthesis
REACT_7970Telomere Maintenance
  logo