MGP Database

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MGP001062

Ontology/Pathway Information

Entrez Gene ID2243
Gene Namefibrinogen alpha chain
Gene Symbol FGA
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0072562 IDA:UniProtKBCblood microparticle
GO:0005938 IEA:EnsemblCcell cortex
GO:0009986 IDA:BHF-UCLCcell surface
GO:0009897 IDA:BHF-UCLCexternal side of plasma membrane
GO:0005576 NAS:UniProtKBCextracellular region
GO:0005615 IDA:BHF-UCLCextracellular space
GO:0070062 IDA:UniProtKBCextracellular vesicular exosome
GO:0005577 IDA:BHF-UCLCfibrinogen complex
GO:0005886 TAS:ReactomeCplasma membrane
GO:0031091 IDA:BHF-UCLCplatelet alpha granule
GO:0031093 TAS:ReactomeCplatelet alpha granule lumen
GO:0031982 IDA:UniProtKBCvesicle
GO:0005198 IDA:BHF-UCLFstructural molecule activity
GO:0007596 TAS:ReactomePblood coagulation
GO:0072377 IMP:BHF-UCLPblood coagulation, common pathway
GO:0007160 IDA:BHF-UCLPcell-matrix adhesion
GO:0043623 IDA:BHF-UCLPcellular protein complex assembly
GO:0030198 TAS:ReactomePextracellular matrix organization
GO:0045087 IEA:UniProtKB-KWPinnate immune response
GO:2000261 TAS:BHF-UCLPnegative regulation of blood coagulation, common pathway
GO:2000352 IDA:BHF-UCLPnegative regulation of endothelial cell apoptotic process
GO:1902042 IDA:BHF-UCLPnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:0030168 TAS:ReactomePplatelet activation
GO:0070527 IMP:UniProtKBPplatelet aggregation
GO:0002576 TAS:ReactomePplatelet degranulation
GO:0070374 IDA:BHF-UCLPpositive regulation of ERK1 and ERK2 cascade
GO:0045921 IDA:BHF-UCLPpositive regulation of exocytosis
GO:0034116 IDA:BHF-UCLPpositive regulation of heterotypic cell-cell adhesion
GO:0090277 IDA:BHF-UCLPpositive regulation of peptide hormone secretion
GO:0050714 IDA:BHF-UCLPpositive regulation of protein secretion
GO:1900026 NAS:BHF-UCLPpositive regulation of substrate adhesion-dependent cell spreading
GO:0045907 IDA:BHF-UCLPpositive regulation of vasoconstriction
GO:0051258 IDA:BHF-UCLPprotein polymerization
GO:0051592 IDA:BHF-UCLPresponse to calcium ion
GO:0007165 IEA:InterProPsignal transduction
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_75925Amyloids
REACT_1439Common Pathway
REACT_116125Disease
REACT_118779Extracellular matrix organization
REACT_2051Formation of Fibrin Clot (Clotting Cascade)
REACT_15443GRB2:SOS provides linkage to MAPK signaling for Integrins
REACT_604Hemostasis
REACT_15523Integrin alphaIIb beta3 signaling
REACT_13552Integrin cell surface interactions
REACT_15381p130Cas linkage to MAPK signaling for integrins
REACT_798Platelet activation, signaling and aggregation
REACT_278Platelet Aggregation (Plug Formation)
REACT_318Platelet degranulation
REACT_1280Response to elevated platelet cytosolic Ca2+
REACT_111102Signal Transduction
SMP Pathway Links
SMP IDDescription
SMP00269Acenocoumarol Action Pathway
SMP00280Alteplase Action Pathway
SMP00286Aminocaproic Acid Action Pathway
SMP00281Anistreplase Action Pathway
SMP00288Aprotinin Action Pathway
SMP00275Ardeparin Action Pathway
SMP00276Argatroban Action Pathway
SMP00277Bivalirudin Action Pathway
SMP00586Coagulation
SMP00656Dicoumarol Action Pathway
SMP00270Dicumarol Action Pathway
SMP00272Enoxaparin Action Pathway
SMP00273Fondaparinux Action Pathway
SMP00274Heparin Action Pathway
SMP00278Lepirudin Action Pathway
SMP00655Phenindione Action Pathway
SMP00271Phenprocoumon Action Pathway
SMP00285Reteplase Action Pathway
SMP00282Streptokinase Action Pathway
SMP00283Tenecteplase Action Pathway
SMP00287Tranexamic Acid Action Pathway
SMP00284Urokinase Action Pathway
SMP00268Warfarin Action Pathway
SMP00279Ximelagatran Action Pathway
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