MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP001071

Record overview

MGPD IDMGP001071
Gene ID2254
SpeciesHomo sapiens (Human)
Gene Namefibroblast growth factor 9
Gene Symbol FGF9
SynonymsGAF; FGF-9; SYNS3; HBFG-9; HBGF-9;
Alternate namesfibroblast growth factor 9; fibroblast growth factor 9 (glia-activating factor); heparin-binding growth factor 9;
Chromosome13
Map Location13q11-q12
SummaryThe protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein was isolated as a secreted factor that exhibits a growth-stimulating effect on cultured glial cells. In nervous system, this protein is produced mainly by neurons and may be important for glial cell development. Expression of the mouse homolog of this gene was found to be dependent on Sonic hedgehog (Shh) signaling. Mice lacking the homolog gene displayed a male-to-female sex reversal phenotype, which suggested a role in testicular embryogenesis. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for FGF9

Proteins

fibroblast growth factor 9 precursor
Refseq ID:NP_002001
Protein GI:4503707
UniProt ID:P31371
mRNA ID:NM_002010
Length:208
RefSeq Status:
MAPLGEVGNYFGVQDAVPFGNVPVLPVDSPVLLSDHLGQSEAGGLPRGPAVTDLDHLKGILRRRQLYCRTGFHLEIFPNGTIQGTRKDHSRFGILEFISI
AVGLVSIRGVDSGLYLGMNEKGELYGSEKLTQECVFREQFEENWYNTYSSNLYKHVDTGRRYYVALNKDGTPREGTRTKRHQKFTHFLPRPVDPDKVPEL
YKDILSQS
 
sig_peptide: 1..3
calculated_mol_wt: 317
peptide sequence: 
MAP

mat_peptide: 4..208
product: fibroblast growth factor 9
calculated_mol_wt: 23141
peptide sequence: 
LGEVGNYFGVQDAVPFGNVPVLPVDSPVLLSDHLGQSEAGGLPRGPAVTDLDHLKGILRRRQLYCRTGFHLEIFPNGTIQGTRKDHSRFGILEFISIAVG
LVSIRGVDSGLYLGMNEKGELYGSEKLTQECVFREQFEENWYNTYSSNLYKHVDTGRRYYVALNKDGTPREGTRTKRHQKFTHFLPRPVDPDKVPELYKD
ILSQS
 
  logo