MGP Database

MGP001073

Ontology/Pathway Information

Entrez Gene ID	2260
Gene Name	fibroblast growth factor receptor 1
Gene Symbol	FGFR1
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0016023	IEA:UniProtKB-SubCell	C	cytoplasmic membrane-bounded vesicle
GO:0005829	IEA:UniProtKB-SubCell	C	cytosol
GO:0005576	NAS:UniProtKB	C	extracellular region
GO:0016021	NAS:UniProtKB	C	integral component of membrane
GO:0005887	TAS:ProtInc	C	integral component of plasma membrane
GO:0005634	IEA:UniProtKB-SubCell	C	nucleus
GO:0005886	IDA:UniProtKB	C	plasma membrane
GO:0043235	IDA:MGI	C	receptor complex
GO:0005524	IEA:UniProtKB-KW	F	ATP binding
GO:0005007	IDA:UniProtKB	F	fibroblast growth factor-activated receptor activity
GO:0017134	IDA:UniProtKB	F	fibroblast growth factor binding
GO:0008201	IDA:UniProtKB	F	heparin binding
GO:0042802	IPI:IntAct	F	identical protein binding
GO:0042803	IPI:UniProtKB	F	protein homodimerization activity
GO:0004713	IDA:UniProtKB	F	protein tyrosine kinase activity
GO:0001525	IEA:Ensembl	P	angiogenesis
GO:0060117	IEA:Ensembl	P	auditory receptor cell development
GO:0007411	TAS:Reactome	P	axon guidance
GO:0060445	IEA:Ensembl	P	branching involved in salivary gland morphogenesis
GO:0048469	IEA:Ensembl	P	cell maturation
GO:0016477	TAS:UniProtKB	P	cell migration
GO:0002062	IEA:Ensembl	P	chondrocyte differentiation
GO:0043009	TAS:UniProtKB	P	chordate embryonic development
GO:0030326	IEA:Ensembl	P	embryonic limb morphogenesis
GO:0007173	TAS:Reactome	P	epidermal growth factor receptor signaling pathway
GO:0038095	TAS:Reactome	P	Fc-epsilon receptor signaling pathway
GO:0008543	IDA:UniProtKB	P	fibroblast growth factor receptor signaling pathway
GO:0035607	IEA:Ensembl	P	fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development
GO:0045087	TAS:Reactome	P	innate immune response
GO:0042472	IEA:Ensembl	P	inner ear morphogenesis
GO:0008286	TAS:Reactome	P	insulin receptor signaling pathway
GO:0001701	IEA:Ensembl	P	in utero embryonic development
GO:0060484	IEA:Ensembl	P	lung-associated mesenchyme development
GO:0000165	TAS:ProtInc	P	MAPK cascade
GO:0048762	IEA:Ensembl	P	mesenchymal cell differentiation
GO:0030901	IEA:Ensembl	P	midbrain development
GO:0042474	IEA:Ensembl	P	middle ear morphogenesis
GO:0000122	IEA:Ensembl	P	negative regulation of transcription from RNA polymerase II promoter
GO:0001764	TAS:UniProtKB	P	neuron migration
GO:0048011	TAS:Reactome	P	neurotrophin TRK receptor signaling pathway
GO:0001759	IEA:Ensembl	P	organ induction
GO:0042473	IEA:Ensembl	P	outer ear morphogenesis
GO:0048339	IEA:Ensembl	P	paraxial mesoderm development
GO:0018108	IDA:UniProtKB	P	peptidyl-tyrosine phosphorylation
GO:0048015	TAS:UniProtKB	P	phosphatidylinositol-mediated signaling
GO:0060045	IEA:Ensembl	P	positive regulation of cardiac muscle cell proliferation
GO:0045787	IEA:Ensembl	P	positive regulation of cell cycle
GO:0008284	IDA:UniProtKB	P	positive regulation of cell proliferation
GO:0043410	IMP:UniProtKB	P	positive regulation of MAPK cascade
GO:0043406	IDA:UniProtKB	P	positive regulation of MAP kinase activity
GO:0090080	IEA:Ensembl	P	positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
GO:0002053	IEA:Ensembl	P	positive regulation of mesenchymal cell proliferation
GO:0045666	IMP:UniProtKB	P	positive regulation of neuron differentiation
GO:0010976	IEA:Ensembl	P	positive regulation of neuron projection development
GO:0014068	TAS:UniProtKB	P	positive regulation of phosphatidylinositol 3-kinase signaling
GO:0010518	TAS:UniProtKB	P	positive regulation of phospholipase activity
GO:0010863	IDA:UniProtKB	P	positive regulation of phospholipase C activity
GO:0046777	IDA:UniProtKB	P	protein autophosphorylation
GO:0006468	NAS:UniProtKB	P	protein phosphorylation
GO:0060665	IEA:Ensembl	P	regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling
GO:0045595	TAS:UniProtKB	P	regulation of cell differentiation
GO:2001239	IEA:Ensembl	P	regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:0048378	IEA:Ensembl	P	regulation of lateral mesodermal cell fate specification
GO:0007605	IEA:Ensembl	P	sensory perception of sound
GO:0001501	TAS:ProtInc	P	skeletal system development
GO:0048705	TAS:UniProtKB	P	skeletal system morphogenesis
GO:0006351	IEA:UniProtKB-KW	P	transcription, DNA-templated
GO:0001657	IEA:Ensembl	P	ureteric bud development
GO:0021847	IEA:Ensembl	P	ventricular zone neuroblast division

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_116125	Disease
REACT_121153	Signaling by activated point mutants of FGFR1
REACT_120999	Signaling by FGFR1 mutants
REACT_120736	Signaling by FGFR in disease
REACT_121398	Signaling by FGFR mutants