MGP Database

MGP001074

Ontology/Pathway Information

Entrez Gene ID	2261
Gene Name	fibroblast growth factor receptor 3
Gene Symbol	FGFR3
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0009986	IEA:Ensembl	C	cell surface
GO:0016023	IEA:UniProtKB-SubCell	C	cytoplasmic membrane-bounded vesicle
GO:0009898	IEA:Ensembl	C	cytoplasmic side of plasma membrane
GO:0005783	IEA:UniProtKB-SubCell	C	endoplasmic reticulum
GO:0005576	IEA:UniProtKB-SubCell	C	extracellular region
GO:0005887	IDA:UniProtKB	C	integral component of plasma membrane
GO:0005764	IEA:Ensembl	C	lysosome
GO:0005634	IEA:Ensembl	C	nucleus
GO:0048471	IEA:Ensembl	C	perinuclear region of cytoplasm
GO:0005886	TAS:Reactome	C	plasma membrane
GO:0005524	IEA:UniProtKB-KW	F	ATP binding
GO:0005007	IMP:UniProtKB	F	fibroblast growth factor-activated receptor activity
GO:0017134	IDA:UniProtKB	F	fibroblast growth factor binding
GO:0004713	IDA:UniProtKB	F	protein tyrosine kinase activity
GO:0061144	IEA:Ensembl	P	alveolar secondary septum development
GO:0060385	IEA:Ensembl	P	axonogenesis involved in innervation
GO:0070977	ISS:BHF-UCL	P	bone maturation
GO:0030282	ISS:BHF-UCL	P	bone mineralization
GO:0060349	TAS:UniProtKB	P	bone morphogenesis
GO:0007267	IEA:Ensembl	P	cell-cell signaling
GO:0022010	IEA:Ensembl	P	central nervous system myelination
GO:0002062	TAS:UniProtKB	P	chondrocyte differentiation
GO:0035988	TAS:UniProtKB	P	chondrocyte proliferation
GO:0090102	IEA:Ensembl	P	cochlea development
GO:0048546	IEA:Ensembl	P	digestive tract morphogenesis
GO:0003416	TAS:UniProtKB	P	endochondral bone growth
GO:0001958	TAS:UniProtKB	P	endochondral ossification
GO:0007173	TAS:Reactome	P	epidermal growth factor receptor signaling pathway
GO:0072148	IEA:Ensembl	P	epithelial cell fate commitment
GO:0038095	TAS:Reactome	P	Fc-epsilon receptor signaling pathway
GO:1902178	IMP:UniProtKB	P	fibroblast growth factor receptor apoptotic signaling pathway
GO:0008543	IDA:UniProtKB	P	fibroblast growth factor receptor signaling pathway
GO:0030900	IEA:Ensembl	P	forebrain development
GO:0045087	TAS:Reactome	P	innate immune response
GO:0060113	IEA:Ensembl	P	inner ear receptor cell differentiation
GO:0008286	TAS:Reactome	P	insulin receptor signaling pathway
GO:0007259	TAS:ProtInc	P	JAK-STAT cascade
GO:0070307	IEA:Ensembl	P	lens fiber cell development
GO:0002089	IEA:Ensembl	P	lens morphogenesis in camera-type eye
GO:0000165	TAS:ProtInc	P	MAPK cascade
GO:0002009	IEA:Ensembl	P	morphogenesis of an epithelium
GO:0048712	IEA:Ensembl	P	negative regulation of astrocyte differentiation
GO:0048640	ISS:BHF-UCL	P	negative regulation of developmental growth
GO:0050680	IEA:Ensembl	P	negative regulation of epithelial cell proliferation
GO:0045839	IEA:Ensembl	P	negative regulation of mitosis
GO:0045879	IEA:Ensembl	P	negative regulation of smoothened signaling pathway
GO:0000122	IEA:Ensembl	P	negative regulation of transcription from RNA polymerase II promoter
GO:0048011	TAS:Reactome	P	neurotrophin TRK receptor signaling pathway
GO:0018108	IDA:UniProtKB	P	peptidyl-tyrosine phosphorylation
GO:0048015	TAS:Reactome	P	phosphatidylinositol-mediated signaling
GO:0090263	IEA:Ensembl	P	positive regulation of canonical Wnt signaling pathway
GO:0045597	IEA:Ensembl	P	positive regulation of cell differentiation
GO:0008284	IMP:UniProtKB	P	positive regulation of cell proliferation
GO:0001938	IEA:Ensembl	P	positive regulation of endothelial cell proliferation
GO:0070374	IMP:UniProtKB	P	positive regulation of ERK1 and ERK2 cascade
GO:0043410	IMP:UniProtKB	P	positive regulation of MAPK cascade
GO:0090080	IEA:Ensembl	P	positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
GO:0043525	IEA:Ensembl	P	positive regulation of neuron apoptotic process
GO:0043552	IMP:UniProtKB	P	positive regulation of phosphatidylinositol 3-kinase activity
GO:0010518	IMP:UniProtKB	P	positive regulation of phospholipase activity
GO:0031398	IEA:Ensembl	P	positive regulation of protein ubiquitination
GO:0042511	IMP:UniProtKB	P	positive regulation of tyrosine phosphorylation of Stat1 protein
GO:0042517	IMP:UniProtKB	P	positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0046777	IDA:UniProtKB	P	protein autophosphorylation
GO:0048678	IEA:Ensembl	P	response to axon injury
GO:0001501	TAS:ProtInc	P	skeletal system development
GO:0035019	IEA:Ensembl	P	somatic stem cell maintenance
GO:0021762	IEA:Ensembl	P	substantia nigra development

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_116125	Disease
REACT_121337	Signaling by activated point mutants of FGFR3
REACT_121249	Signaling by FGFR3 mutants
REACT_120736	Signaling by FGFR in disease
REACT_121398	Signaling by FGFR mutants
REACT_121011	t(4;14) translocations of FGFR3