MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP001077

Ontology/Pathway Information

Entrez Gene ID2264
Gene Namefibroblast growth factor receptor 4
Gene Symbol FGFR4
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005737 IDA:HPACcytoplasm
GO:0005783 IDA:UniProtKBCendoplasmic reticulum
GO:0005768 IEA:UniProtKB-SubCellCendosome
GO:0005576 IEA:UniProtKB-SubCellCextracellular region
GO:0005887 IDA:UniProtKBCintegral component of plasma membrane
GO:0005654 IDA:HPACnucleoplasm
GO:0005886 TAS:ReactomeCplasma membrane
GO:0005524 IEA:UniProtKB-KWFATP binding
GO:0005007 IDA:UniProtKBFfibroblast growth factor-activated receptor activity
GO:0017134 IDA:UniProtKBFfibroblast growth factor binding
GO:0008201 IDA:UniProtKBFheparin binding
GO:0004713 TAS:ReactomeFprotein tyrosine kinase activity
GO:0061144 IEA:EnsemblPalveolar secondary septum development
GO:0016477 IMP:UniProtKBPcell migration
GO:0007173 TAS:ReactomePepidermal growth factor receptor signaling pathway
GO:0038095 TAS:ReactomePFc-epsilon receptor signaling pathway
GO:0008543 IDA:UniProtKBPfibroblast growth factor receptor signaling pathway
GO:0042593 ISS:UniProtKBPglucose homeostasis
GO:0045087 TAS:ReactomePinnate immune response
GO:0008286 TAS:ReactomePinsulin receptor signaling pathway
GO:0048011 TAS:ReactomePneurotrophin TRK receptor signaling pathway
GO:0001759 IEA:EnsemblPorgan induction
GO:0018108 IDA:UniProtKBPpeptidyl-tyrosine phosphorylation
GO:0055062 ISS:UniProtKBPphosphate ion homeostasis
GO:0048015 TAS:ReactomePphosphatidylinositol-mediated signaling
GO:0008284 IDA:UniProtKBPpositive regulation of cell proliferation
GO:2000573 IMP:UniProtKBPpositive regulation of DNA biosynthetic process
GO:0070374 IMP:UniProtKBPpositive regulation of ERK1 and ERK2 cascade
GO:0048554 IMP:UniProtKBPpositive regulation of metalloenzyme activity
GO:0045862 IMP:UniProtKBPpositive regulation of proteolysis
GO:0046777 IDA:UniProtKBPprotein autophosphorylation
GO:0070857 IMP:UniProtKBPregulation of bile acid biosynthetic process
GO:2000188 ISS:UniProtKBPregulation of cholesterol homeostasis
GO:0010715 IMP:UniProtKBPregulation of extracellular matrix disassembly
GO:0019216 ISS:UniProtKBPregulation of lipid metabolic process
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_75774Adaptive Immune System
REACT_111046betaKlotho-mediated ligand binding
REACT_147727Constitutive PI3K/AKT Signaling in Cancer
REACT_147694DAP12 interactions
REACT_147814DAP12 signaling
REACT_116125Disease
REACT_118638Downstream signaling events of B Cell Receptor (BCR)
REACT_21272Downstream signaling of activated FGFR
REACT_17025Downstream signal transduction
REACT_163936Fc epsilon receptor (FCERI) signaling
REACT_9452FGFR4 ligand binding and activation
REACT_9396FGFR ligand binding and activation
REACT_21247FRS2-mediated cascade
REACT_12578GAB1 signalosome
REACT_150210IGF1R signaling cascade
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_1195Insulin receptor signalling cascade
REACT_332IRS-mediated signalling
REACT_762IRS-related events
REACT_150203IRS-related events triggered by IGF1R
REACT_111247Klotho-mediated ligand binding
REACT_111184Negative regulation of FGFR signaling
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_21310Phospholipase C-mediated cascade
REACT_12464PI3K/AKT activation
REACT_147723PI3K/AKT Signaling in Cancer
REACT_21270PI-3K cascade
REACT_976PI3K Cascade
REACT_116008PI3K events in ERBB2 signaling
REACT_115961PI3K events in ERBB4 signaling
REACT_75829PIP3 activates AKT signaling
REACT_163769Role of LAT2/NTAL/LAB on calcium mobilization
REACT_21374SHC-mediated cascade
REACT_9417Signaling by EGFR
REACT_115871Signaling by EGFR in Cancer
REACT_268269Signaling by EGFRvIII in Cancer
REACT_115755Signaling by ERBB2
REACT_115596Signaling by ERBB4
REACT_9470Signaling by FGFR
REACT_121286Signaling by FGFR4 mutants
REACT_120736Signaling by FGFR in disease
REACT_121398Signaling by FGFR mutants
REACT_498Signaling by Insulin receptor
REACT_268006Signaling by Ligand-Responsive EGFR Variants in Cancer
REACT_268546Signaling by Overexpressed Wild-Type EGFR in Cancer
REACT_16888Signaling by PDGF
REACT_111040Signaling by SCF-KIT
REACT_118773Signaling by the B Cell Receptor (BCR)
REACT_150359Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
REACT_11061Signalling by NGF
REACT_111102Signal Transduction
  logo