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MGP001084

Record overview

MGPD IDMGP001084
Gene ID2281
SpeciesHomo sapiens (Human)
Gene NameFK506 binding protein 1B, 12.6 kDa
Gene Symbol FKBP1B
SynonymsOTK4; FKBP1L; PKBP1L; PPIase; FKBP12.6;
Alternate namespeptidyl-prolyl cis-trans isomerase FKBP1B; 12.6 kDa FK506-binding protein; 12.6 kDa FKBP; FK506-binding protein 12.6; FK506-binding protein 1B; FKBP-12.6; FKBP-1B; PPIase FKBP1B; calstabin 2; h-FKBP-12; immunophilin FKBP12.6; rotamase;
Chromosome2
Map Location2p23.3
EC Number5.2.1.8
SummaryThe protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It is highly similar to the FK506-binding protein 1A. Its physiological role is thought to be in excitation-contraction coupling in cardiac muscle. There are two alternatively spliced transcript variants of this gene encoding different isoforms. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for FKBP1B

Proteins

peptidyl-prolyl cis-trans isomerase FKBP1B isoform a
Refseq ID:NP_004107
Protein GI:4758380
UniProt ID:P68106
mRNA ID:NM_004116
Length:108
RefSeq Status:
MGVEIETISPGDGRTFPKKGQTCVVHYTGMLQNGKKFDSSRDRNKPFKFRIGKQEVIKGFEEGAAQMSLGQRAKLTCTPDVAYGATGHPGVIPPNATLIF
DVELLNLE
 
peptidyl-prolyl cis-trans isomerase FKBP1B isoform b
Refseq ID:NP_473374
Protein GI:17149839
UniProt ID:P68106
mRNA ID:NM_054033
Length:80
RefSeq Status:
MGVEIETISPGDGRTFPKKGQTCVVHYTGMLQNGKKFDSSRDRNKPFKFRIGKQEVIKGFEEGAAQLGPLSPLPICPHPC
 
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